Serum levels of anti-heat shock protein 27 antibodies in patients with chronic liver disease
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ORIGINAL PAPER
Serum levels of anti-heat shock protein 27 antibodies in patients with chronic liver disease Gabriella Gruden 1 & Patrizia Carucci 2 & Federica Barutta 1 & Davina Burt 1 & Arianna Ferro 1 & Emanuela Rolle 2 & Silvia Pinach 1 & Maria Lorena Abate 2 & Donata Campra 3 & Marilena Durazzo 1 Received: 30 May 2020 / Revised: 29 August 2020 / Accepted: 1 September 2020 # Cell Stress Society International 2020
Abstract Heat shock protein 27 (HSP27), an intracellular molecular chaperone, is involved in the pathogenesis of cancer by promoting both tumor cell proliferation and resistance to therapy. HSP27 is also present in the circulation and circulating HSP27 (sHSP27) can elicit an autoimmune response with production of antibodies. Levels of sHSP27 are enhanced in patients with hepatocellular carcinoma (HCC); it is, however, unknown whether changes in HSP27 antibody levels occur in patients with HCC and can be exploited as a circulating biomarker of HCC. Our aim was to assess the potential association between newly diagnosed HCC and serum anti-HSP27 antibody levels. In this cross-sectional study, anti-HSP27 antibody levels were measured in serum samples from 71 HCC patients, 80 subjects with chronic liver disease, and 38 control subjects by immunoenzymatic assay. Anti-HSP27 antibody levels did not differ significantly among groups. However, in patients with chronic active hepatitis/cirrhosis, antiHSP27 levels were significantly higher in subjects with a positive history of alcoholism (p = 0.03). Our data do not support the hypothesis that anti-HSP27 antibody levels may help identify patients with HCC among subjects with chronic liver disease. However, our finding that alcohol-related liver disease is associated with higher anti-HSP27 levels is novel and deserves further investigations. Keywords Anti-heat shock protein 27 antibodies . Hepatocellular carcinoma . Liver cirrhosis . Chronic liver disease
Introduction Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and usually develops on a background of chronic liver disease. The death rate from HCC has dramatically increased in the last decades (Xu 2018), while patient survival has improved minimally, making HCC the fourth most common cause of cancer-related death. Because of the lack of specific markers for HCC, early diagnosis and prognostic assessment are difficult, and there is increasing quest for novel HCC biomarkers.
* Gabriella Gruden [email protected] 1
Department of Medical Science, University of Turin, Turin, Italy
2
Department of Gastro-Hepatology, Città della Salute e della Scienza, Turin, Italy
3
Department of Surgery, Città della Salute e della Scienza, Turin, Italy
Heat shock proteins (HSPs) are a large family of proteins highly conserved throughout evolution because of their unique cytoprotective function. HSP27 (also named HSPB1) is a member of the small HSP family and is induced by heat and cellular stresses. Besides assisting protein refolding and regulating proteostasis under stressful condition
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