Serum Magnesium and Fractional Exhaled Nitric Oxide in Relation to the Severity in Asthma-Chronic Obstructive Pulmonary
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Serum Magnesium and Fractional Exhaled Nitric Oxide in Relation to the Severity in Asthma-Chronic Obstructive Pulmonary Disease Overlap Mingzhi Ye 1 & Qianhong Li 1 & Ling Xiao 1 & Zhongsheng Zheng 1 Received: 21 March 2020 / Accepted: 29 July 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Serum concentrations of magnesium and manganese may be associated with increased chronic obstructive pulmonary disease exacerbation risk. However, associations with other aspects of asthma-chronic obstructive pulmonary disease overlap, pulmonary function test results and health status, have been studied less extensively. The aim of this study was to investigate the associations between serum concentrations of trace elements and T lymphocyte subsets, FeNO, and COPD-related questionnaire scores in individuals with ACO and the potential impact of these parameters on lung function. All the patients met the diagnostic criteria of ACO and were divided into two groups (group A, mild–moderate; group B, severe–very severe) by their specific characteristics. Pulmonary function testing and serum Mg and serum Mn and FeNO were measured. Four hundred sixty-five patients were screened, and 42 were included. Group A had significantly higher Mg and Fe concentrations than group B. No significant differences were seen in the serum concentration of any other trace element between the two groups. Serum Mg and Mn were correlated with FEV1% predicted (p < 0.01). Group A had a significantly higher FeNO concentration than group B (p = 0.005). The scores on CAT (p = 0.011) and mMRC (p = 0.008) in group A were lower than in group B. The low-FeNO group had a significantly lower concentration of serum Mg than the high-FeNO group (p = 0.03). Pulmonary function declined faster (p < 0.05) in the low-FeNO group than the high-FeNO group. Serum Mg concentration may indicate protective effects against lung function loss in ACO. This implies that FeNO might be a biomarker for identifying individuals with ACO who might benefit from inhaled corticosteroid therapy. Serum Mg and FeNO were associated with ACO severity. However, their role in guiding personalised treatment of individuals with ACO needs to be further investigated. Keywords Magnesium . Manganese . FEV1 . FENO . ACO
Introduction Chronic obstructive pulmonary disease (COPD), which is a preventable and treatable disease, is gradually increasing in prevalence worldwide due to smoking habits and environmental pollution, accompanied by the increase in the elderly population. It has a significant effect on quality of life, symptoms, Mingzhi Ye, Qianhong Li, Ling Xiao and Zhongsheng Zheng contributed equally to this work. Mingzhi Ye and Qianhong Li were co first authors. Ling Xiao and Zhongsheng Zheng were co correspondents. * Zhongsheng Zheng [email protected]; [email protected] 1
Department of Respiratory, the First Affiliated Hospital of Shantou University Medical College, No.57 at Changping Road, Jinping District, Shantou City 515041, Guangdong Province, People’s Republic
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