Signet ring cell component in pretreatment biopsy predicts pathological response to preoperative chemoradiotherapy in re
- PDF / 1,391,190 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 8 Downloads / 183 Views
ORIGINAL ARTICLE
Signet ring cell component in pretreatment biopsy predicts pathological response to preoperative chemoradiotherapy in rectal cancer Xue Chao1,2 · Zixian Wang1,3 · Shixun Lu1,2 · Yuhua Huang1,2 · Shengbing Zang1,2 · Peirong Ding1,4 · Huizhong Zhang1,2,5 · Jingping Yun1,2,5 Received: 23 January 2020 / Accepted: 4 May 2020 © Japan Society of Clinical Oncology 2020
Abstract Purpose Neoadjuvant therapy is routinely used in the management of locally advanced rectal cancer. This study aimed to evaluate the predictive value of pathological parameters in tumor response after treatment. Methods We reviewed the hematoxylin–eosin slides from pretreatment biopsies of 150 rectal cancer patients who received preoperative chemoradiotherapy (PCRT) at Sun Yat-sen University Cancer Center between May 2013 and June 2016. Pathological and clinical parameters were both studied. The tumor response after chemoradiotherapy was evaluated using the tumor regression grade (TRG). Logistic regression was used to evaluate the relevance between these parameters and tumor response. Results Complete tumor response (TRG0 and pCR) to PCRT was identified in 40 (26.7%) patients. The pCR rate was 93.33% (14 of 15) in cases with signet ring cell component versus 19.26% (26 of 135) in those without signet ring cell component (p 50% of tumor cells with prominent intracytoplasmic mucin, typically with displacement and molding of the nucleus [14]. SRCC has been reported to have a worse prognosis, especially in the late stage, according to previous studies [12, 13, 15]. Rectal SRCC patients had a poor 5-year relative survival of 19.5% (95% CI 14.7–24.8%) compared with 58.5% (95% CI 57.9–59.1%) for conventional adenocarcinoma [16]. However, a study involving 292 SRCC patients showed that preoperative radiotherapy significantly improved survival outcomes [17]. Additionally, prior studies have suggested that SRCC might be a favorable predictor of pCR after PCRT, but these studies were limited by small sample size [18, 19]. Furthermore, the association between adenocarcinoma with 50% of signet ring cells. For those with
Data Loading...
