Skin Recovery After Discontinuation of Long-Term Moisturizer Application: A Split-Face Comparison Pilot Study
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ORIGINAL RESEARCH
Skin Recovery After Discontinuation of Long-Term Moisturizer Application: A Split-Face Comparison Pilot Study Julia-Tatjana Maul . Lara Valeska Maul . Marc Ka¨gi . Phil Cheng . Florian Anzengruber . Mathilde von Laue . Yuki Chen . Martin Ka¨gi . Alexander Navarini
Received: August 12, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Facial moisturizers are commonly used by healthy women and increasingly men of all age groups. This study aimed to investigate the effects of moisturizer discontinuation and the subsequent evolution of symptoms. Methods: Two prospective observational splitface comparison pilot studies were performed in Julia-Tatjana Maul and Lara Valeska Maul contributed equally to this work.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13555020-00453-0) contains supplementary material, which is available to authorized users. J.-T. Maul (&) P. Cheng F. Anzengruber Department of Dermatology, University Hospital of ¨ rich, Zurich, Switzerland Zu e-mail: [email protected] L. V. Maul A. Navarini Department of Dermatology, University Hospital of Basel, Basel, Switzerland M. Ka¨gi M. von Laue M. Ka¨gi ¨ rich, Zurich, Faculty of Medicine, University of Zu Switzerland Y. Chen Faculty of Medicine, University of Bern, Bern, Switzerland M. Ka¨gi M. Ka¨gi ¨ rich AG, Zurich, Switzerland Hautzentrum, Zu
Switzerland and enrolled (I) 20 healthy women aged 17–25 years in winter and (II) 36 female subjects 15–20 and 40–55 years of age in summer. Moisturizers were stopped on the investigational half of the face. On the control side, the usual skin care regimen was continued. Daily subjective (I/II) and objective (I) skin assessments for the occurrence of typical symptoms of dry skin (dryness, itching, scales, redness, wrinkles) were collected. Results: In the winter study (cohort I) in both the subjective and objective assessment, all skin changes increased significantly within 1 day after discontinuation. On day 7, dryness (p \ 0.001), itching (p \ 0.025), redness (p \ 0.001) and scales (p \ 0.049) were significantly different in the subjective assessment and redness (p \ 0.004) and scales (p \ 0.001) in the objective assessment. Skin dryness reverted to baseline levels after 6 days in the objective assessment and 10 days in the subjective assessment. The control side’s condition was reached after 6 days. In the summer study (II), only among the 15–20-year-olds was dryness significantly higher on the intervention side from day 1 (p \ 0.028) to day 14 (p \ 0.009). Their recovery time was 11 days until dryness intensity scores comparable to baseline were reached, and 21 days until the control side’s values were matched. Over a 7-day period, the overall mean dryness score was significantly different between the interventional and control sides for both young and old participants.
Dermatol Ther (Heidelb)
Conclusions: Both healthy young and aging female subjects react with typical symptoms of temporary dryness to a sudden stop of a
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