Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters d

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Michael B. A. Oldstone Hugh Rosen Editors

Sphingosine-1Phosphate Signaling in Immunology and Infectious Diseases

Current Topics in Microbiology and Immunology Volume 378 Series editors Klaus Aktories Medizinische Fakultät, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Abt. I Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany Richard W. Compans Department of Microbiology and Immunology, Emory University, 1518 Clifton Road, CNR 5005, Atlanta, GA 30322, USA Max D. Cooper Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462 Clifton Road, Atlanta, GA 30322, USA Jorge E. Galan Boyer Ctr. for Molecular Medicine, School of Medicine, Yale University, 295 Congress Avenue, room 343, New Haven, CT 06536-0812, USA Yuri Y. Gleba Nomad Bioscience GmbH, Biozentrum Halle, Weinbergweg 22, 06120 Halle, Germany Tasuku Honjo Faculty of Medicine, Department of Medical Chemistry, Kyoto University, Sakyo-ku, Yoshida, Kyoto 606-8501, Japan Yoshihiro Kawaoka School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA Bernard Malissen Centre d’Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France Michael B. A. Oldstone Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Rino Rappuoli Novartis Vaccines & Diagnostics S.r.l., Via Fiorentina 1, Siena 53100, Italy Peter K. Vogt Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-239, La Jolla, CA 92037, USA Honorary Editor: Hilary Koprowski (deceased) Formerly at Biotechnology Foundation, Inc., Ardmore, PA, USA

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Michael B. A. Oldstone Hugh Rosen •

Editors

Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases Responsible series editor: Michael B. A. Oldstone

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Editors Michael B. A. Oldstone Department of Immunology and Microbial Science The Scripps Research Institute La Jolla, CA USA

Hugh Rosen Department of Chemical Physiology The Scripps Research Institute La Jolla, CA USA

ISSN 0070-217X ISSN 2196-9965 (electronic) ISBN 978-3-319-05878-8 ISBN 978-3-319-05879-5 (eBook) DOI 10.1007/978-3-319-05879-5 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014937305  Springer International Publishing Switzerland 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with