Spleen contraction elevates hemoglobin concentration at high altitude during rest and exercise
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ORIGINAL ARTICLE
Spleen contraction elevates hemoglobin concentration at high altitude during rest and exercise Erika Schagatay1,2 · Alexander Lunde1 · Simon Nilsson1 · Oscar Palm1 · Angelica Lodin‑Sundström1,3 Received: 2 October 2019 / Accepted: 10 August 2020 © The Author(s) 2020
Abstract Purpose Hypoxia and exercise are known to separately trigger spleen contraction, leading to release of stored erythrocytes. We studied spleen volume and hemoglobin concentration (Hb) during rest and exercise at three altitudes. Methods Eleven healthy lowlanders did a 5-min modified Harvard step test at 1370, 3700 and 4200 m altitude. Spleen volume was measured via ultrasonic imaging and capillary Hb with Hemocue during rest and after the step test, and arterial oxygen saturation (SaO2), heart rate (HR), expiratory CO2 (ETCO2) and respiratory rate (RR) across the test. Results Resting spleen volume was reduced with increasing altitude and further reduced with exercise at all altitudes. Mean (SE) baseline spleen volume at 1370 m was 252 (20) mL and after exercise, it was 199 (15) mL (P
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