Sporotrichosis New Developments and Future Prospects
The book presents current affairs of Sporotrichosis as emergent disease with emphasis on the potential factors associated with genetic polymorphisms in Sporothrix complex. Constitutive and inducible factors play an essential role in the response of t
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Sporotrichosis New Developments and Future Prospects
Sporotrichosis
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Iracilda Zeppone Carlos Editor
Sporotrichosis New Developments and Future Prospects
Editor Iracilda Zeppone Carlos Faculdade de Cieˆncias Farmaceˆuticas Universidade Estadual Paulista Ju´lio Mesquita Filho UNESP Araraquara, Sa˜o Paulo Brazil
ISBN 978-3-319-11911-3 ISBN 978-3-319-11912-0 DOI 10.1007/978-3-319-11912-0
(eBook)
Library of Congress Control Number: 2015954970 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
To my lovely husband Manoel and our sons, Julio, Esteva˜o, and Manoela
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Preface
Until recently, sporotrichosis has been considered a neglected disease. Despite its worldwide spread with numerous hyperendemic areas, and being the most frequent subcutaneous mycosis in large geographical areas such as South America, as well as outbreaks occurring in several tropical and subtropical countries, references in the basic literature citing sporotrichosis as an example of human mycosis are still rare. Several factors have contributed to an increased interest in this disease. As an opportunistic infection, its incidence has been associated with risk groups such as patients infected with human immunodeficiency virus or receiving immunosuppressive therapies, and patients with chronic diseases, among others. Another point of great interest regards sporotrichosis becoming an important zoonosis. This has changed the classic epidemiological pattern shaped by many years of soil-associated transmission, frequently through punctures from thorns; hence the name ‘rose gardener’s disease’. Several advances have been made in terms of comprehending the biology of Sporothrix schenckii and the pathogenesis of sporotrichosis. This book aims to consolidate these ma
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