Stiff-Person Syndrome and Related Disorders A Comprehensive, Practic
This comprehensive title covers all of the broad aspects of stiff-person spectrum disorders (SPSD), ranging from clinical features and laboratory investigations to the basic scientific roles of neuroimmunology and genetics that aid clinicians in understan
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Stiff-Person Syndrome and Related Disorders
Pichet Termsarasab Thananan Thammongkolchai Bashar Katirji
Stiff-Person Syndrome and Related Disorders A Comprehensive, Practical Guide
Pichet Termsarasab Division of Neurology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand
Thananan Thammongkolchai Division of Neurology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand
Bashar Katirji Department of Neurology University Hospitals Cleveland Medical Center Case Western Reserve University Cleveland, OH USA
ISBN 978-3-030-43058-0 ISBN 978-3-030-43059-7 (eBook) https://doi.org/10.1007/978-3-030-43059-7 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
We would like to dedicate this book to our families. For PT – to my partner, Ploy; parents, Boonreun and Veerachai; grandma, Lung and Prapai; and the Chomchai family. For TT – to my husband, PT, for all his support; my parents, Suchin and Waraporn; and my lovely sisters, Tahn and Pink. For BK – to my wife, Patricia, and my two children, Linda and Michael, as well as my parents, Malak and Zakarea.
Preface
Stiff-person syndrome (SPS), originally called stiff-man syndrome, is actually a group of disorders in which knowledge and understanding have been evolving rapidly in the past few decades. As one can appreciate from the name transition, this group of disorders affects men and women, thus the name change from “stiff-man syndrome” to “stiff-person syndrome.” With the rapid evolution in the neuroimmunology field, various different antibodies, in addition to anti-glutamic acid decarboxylase (anti-GAD), with their associated phenotypes have been inc
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