Supplementation of Taurine Insulates Against Oxidative Stress, Confers Neuroprotection and Attenuates Memory Impairment
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ORIGINAL PAPER
Supplementation of Taurine Insulates Against Oxidative Stress, Confers Neuroprotection and Attenuates Memory Impairment in Noise Stress Exposed Male Wistar Rats Saida Haider1 · Irfan Sajid1,2 · Zehra Batool3 · Syeda Madiha1 · Sadia Sadir1 · Noor Kamil4 · Laraib Liaquat1 · Saara Ahmad5 · Saiqa Tabassum1,6 · Saima Khaliq2 Received: 2 June 2020 / Revised: 7 August 2020 / Accepted: 5 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Noise has always been an important environmental factor that induces health problems in the general population. Due to ever increasing noise pollution, humans are facing multiple auditory and non-auditory problems including neuropsychiatric disorders. In modern day life it is impossible to avoid noise due to the rapid industrialization of society. Continuous exposure to noise stress creates a disturbance in brain function which may lead to memory disorder. Therefore, it is necessary to find preventive measures to reduce the deleterious effects of noise exposure. Supplementation of taurine, a semi essential amino acid, is reported to alleviate psychiatric disorders. In this study noise-exposed (100 db; 3 h daily for 15 days) rats were supplemented with taurine at a dose of 100 mg/kg for 15 days. Spatial and recognition memory was assessed using the Morris water maze and novel object recognition task, respectively. Results of this study showed a reversal of noise-induced memory impairment in rats. The derangements of catecholaminergic and serotonergic levels in the hippocampus and altered brain antioxidant enzyme activity due to noise exposure were also restored by taurine administration. This study highlights the importance of taurine supplementation to mitigate noise-induced impaired memory via normalizing the neurochemical functions and reducing oxidative stress in rat brain. Keywords Noise stress · Taurine · Memory function · Biogenic amines · Oxidative stress Abbreviations 5-HIAA 5-Hydroxyindoleacetic acid 5-HT C5-hydroxytryptamine * Zehra Batool [email protected] 1
Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan
2
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
3
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and BiologicalSciences, University of Karachi, Karachi 75270, Pakistan
4
Department of Basic Medical Sciences, Faculty of Pharmacy, Barrett Hodgson University, Karachi, Pakistan
5
Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan
6
Department of Biochemistry, Shaheed Zuifiqar Ali Bhutto Institute of Science and Technology, Karachi, Pakistan
AChE Acetylocholinesterase CAT Catalase DOPAC Dihydroxyphenylacetic acid DA Dopamine FST Force swim test GPx Glutathione peroxidase HPLC-EC High performance liquid chromatography with an electrochemical detector L
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