Surgical castration versus chemical castration in donkeys: response of stress, lipid profile and redox potential biomark
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(2020) 16:310
RESEARCH ARTICLE
Open Access
Surgical castration versus chemical castration in donkeys: response of stress, lipid profile and redox potential biomarkers Nasser S. Abou-Khalil1, Marwa F. Ali2, Magda M. Ali3 and Ahmed Ibrahim4*
Abstract Background: Castration is a husbandry practice raising important questions on the welfare and physiological status of farm animals. Searching for effective castration methods that minimally compromise the body physiology is worthy of attention. Therefore, this study aimed to evaluate the differential response of biological systems in donkeys to surgical castration versus the chemical one by CaCl2 with special emphasis on stress, lipid profile, and oxidative stress biomarkers. Donkeys were divided randomly and equally into two groups; the chemical (Ch) and surgical (S) groups (n = 6). The Ch group was chemically castrated by intratesticular injection of 20% CaCl2 dissolved in absolute ethanol. Blood samples were collected prior to castration and at 15, 30, 45, and 60 days after the beginning of experiment. Results: Surprisingly, the Ch group at the end of the experiment was characterized by significantly higher cortisol level compared to the S group. TC and LDL-C levels in the S group significantly decreased at day 45, while TG levels significantly increased at days 45 and 60 in comparison with day 0. HDL-C levels at days 30 and 60 in the Ch group significantly increased in comparison with day 0. At day 30 post-castration, HDL-C was significantly higher and LDL-C was significantly lower in the Ch group than the S group. A significant elevation in TC and LDL-C was observed at day 45 and in HDL-C at the end of experimental duration in the Ch group when compared with the S group. TPX level was significantly lower and TAC was significantly higher in the Ch group at day 45 than the S group. Conclusion: Surgical castration evoked less stress and minor changes in lipid profile and oxidant/antioxidant balance relative to chemical castration by intratesticular 20% CaCl2 dissolved in absolute ethanol. Keywords: Surgical castration, Chemical castration, Physiology, Stress, Lipid profile, Oxidative stress
Background Our previous study revealed that a single bilateral intratesticular injection of 20% calcium chloride (CaCl2) dissolved in absolute ethanol in donkeys was ineffective in reducing serum testosterone levels over 60 days postcastration in contrast to the surgical castration using the scrotal ablation technique [1]. In continuation of this * Correspondence: [email protected] 4 Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Assiut University, Assiut 71526, Egypt Full list of author information is available at the end of the article
work, we decided to examine the difference in the effects of these two types of castration on some physiologically relevant parameters. Although CaCl2 castration seems to be an appropriate non-surgical strategy in the terms of efficacy, cost, animal welfare and metabolic issues in albino rats, cats, dogs, and Black Bengal goats
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