T-Type Calcium Channels and Epilepsy
Epilepsy is characterized by spontaneous recurrent seizures in which electrical activity in particular brain regions becomes over-excitable. As different brain regions interact in cycle, one excites the next until they become locked into a self-propagatin
- PDF / 10,659,416 Bytes
- 725 Pages / 453.543 x 683.15 pts Page_size
- 95 Downloads / 164 Views
Pathologies of Calcium Channels
Pathologies of Calcium Channels
Norbert Weiss Alexandra Koschak •
Editors
Pathologies of Calcium Channels
123
Editors Norbert Weiss Department of Physiology and Pharmacology, Hotchkiss Brain Institute University of Calgary Calgary Canada
ISBN 978-3-642-40281-4 DOI 10.1007/978-3-642-40282-1
Alexandra Koschak Department of Neurophysiology and Pharmacology Medical University Vienna Vienna Austria
ISBN 978-3-642-40282-1
(eBook)
Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013951126 Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Calcium signaling is a highly versatile system responsible for regulating a large number of diverse cell functions in both excitable and non-excitable cells. It initiates a new life at the time of fertilization and then guides many of the subsequent developmental processes that orchestrate the emergence of all the multiple cell types that constitute all the organ systems of the human body. The enormous diversity and subtlety of these different signaling systems is quite remarkable. At synaptic endings, for example, a brief highly localized pulse of calcium can trigger transmitter release within microseconds, wh
Data Loading...
