Taste receptor polymorphisms and longevity: a systematic review and meta-analysis
- PDF / 927,681 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 18 Downloads / 133 Views
REVIEW
Taste receptor polymorphisms and longevity: a systematic review and meta‑analysis Danilo Di Bona1 · Alberto Malovini2 · Giulia Accardi3 · Anna Aiello3 · Giuseppina Candore3 · Anna Ferrario4 · Mattia E. Ligotti3 · Anna Maciag4 · Annibale A. Puca4,5 · Calogero Caruso3 Received: 15 June 2020 / Accepted: 22 October 2020 © The Author(s) 2020
Abstract Bitter taste receptors (TAS2R) are involved in a variety of non-tasting physiological processes, including immune-inflammatory ones. Therefore, their genetic variations might influence various traits. In particular, in different populations of South Italy (Calabria, Cilento, and Sardinia), polymorphisms of TAS2R16 and TAS238 have been analysed in association with longevity with inconsistent results. A meta-analytic approach to quantitatively synthesize the possible effect of the previous variants and, possibly, to reconcile the inconsistencies has been used in the present paper. TAS2R38 variants in the Cilento population were also analysed for their possible association with longevity and the obtained data have been included in the relative meta-analysis. In population from Cilento no association was found between TAS2R38 and longevity, and no association was observed as well, performing the meta-analysis with data of the other studies. Concerning TAS2R16 gene, instead, the genotype associated with longevity in the Calabria population maintained its significance in the meta-analysis with data from Cilento population, that, alone, were not significant in the previously published study. In conclusion, our results suggest that TAS2R16 genotype variant is associated with longevity in South Italy. Keywords Immune-inflammatory responses · Longevity · Meta-analysis · Taste receptors
Introduction
Danilo Di Bona and Alberto Malovini contributed equally to this work. * Calogero Caruso [email protected] 1
Department of Emergency and Organ Transplantation, University of Bari-Aldo Moro, Bari, Italy
2
Laboratory of Informatics and Systems Engineering for Clinical Research, Clinical Scientific Institutes Maugeri, 27100 Pavia, Italy
3
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Technologies, University of Palermo, Corso Tuköry, 211, 90134 Palermo, Italy
4
Cardiovascular Research Unit, IRCCS MultiMedica, 20138 Milan, Italy
5
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, SA, Italy
The sensory structures for taste are the taste buds, groups of cells contained in goblet-shaped structures, papillae. The taste receptor cells occur in taste buds in groups of 50–150. Taste receptors are found on the upper surface of the tongue, soft palate, upper oesophagus, the cheek, and epiglottis. On average, there are 2000–8000 taste buds on the human tongue, therefore, hundreds of thousands of receptor cells. However, there is a great variety in their number. Healthy humans may have from three to several thousand taste buds per square centimetr
Data Loading...
