Tenofovir disoproxil fumarate
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Tenofovir disoproxil fumarate Renal toxicity: case report A man [age not stated] with hepatitis B virus infection, treated with adefovir, was switched to tenofovir disoproxil fumarate [dosage not stated] because of adefovir resistance. His viraemia dropped to below detectable limits 56 weeks after starting tenofovir; however, tenofovir had to be withdrawn due to the development of drug-induced renal toxicity [duration of therapy to reaction onset not stated]. He was switched to entecavir, which resulted in a moderate but remarkable increase in his viraemia [patient outcome not stated]. Schildgen O, et al. Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy. Journal of Clinical Microbiology 48: 631-634, No. 2, Feb 2010. Available from: URL: http://dx.doi.org/10.1128/ 803008589 JCM.01073-09 - Germany
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Reactions 27 Mar 2010 No. 1294
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