Testosterone Action - Deficiency - Substitution

New developments in testosterone action and therapy are summarized here by internationally renowned experts. They review both basic and clinical knowledge in 20 chapters. This 2nd edition has been thoroughly revised and extended. The book presents the bio

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Testosterone

Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Santa Clara Singapore Tokyo

E. Nieschlag H. M. Behre (Eds.)

Testosterone Action - Deficiency - Substitution Second Edition Editorial Assistant: S. Nieschlag With Contributions by 1. E. Atkinson H. M. Behre S. Bhasin R. Bross R. Casaburi Y.-L. Chang K. Christiansen B. Couzinet A. von Eckardstein J. S. Finkelstein J. Frick L.J. Gooren D. J. Handelsman A. Jungwirth J.M. Kaufman P. Y. Liu W.A. Meikle E. Nieschlag C.A. Quigley Y.A. Randall EEG. Rommerts E. Rovan G. Schaison W. Schanzer P.J. Snyder T. W. Storer A. Vermeulen G. E Weinbauer

With 95 Figures and 28 Tables

,

Springer

Prof. Dr. med. Eberhard Nieschlag Priv.-Doz. Dr. med. Hermann M. Behre Institute of Reproductive Medicine, University of Munster Domagkstrasse 11, D-48129 Munster, Germany

Editorial Assistant: Susan Nieschlag, MA

ISBN -13: 978-3-642-72187-8 e-ISBN -13: 978-3-642-72185-4 DOl: 10.1007/978-3-642-72185-4 Library of Congress Cataloging-in Publication Data Testosterone: action, deficiency, substitution / E. Nieschlag, H. M. Behre (eds.); editorial assistant, S. Nieschlag; with contributions by L. E. Atkinson ... [et al.]. - 2nd ed. Includes bibliographical references and index. ISBN-13:978-3-642-72187-8 1.Testosterone - Therapeutic use. 2. Testosterone - Physiological effect. 1. Nieschlag. E. II. Behre, H.M. (Hermann M.), 1961- . RM296.5.T47T47 1998 615'.366-dc21 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1990, 1998

Softcover reprint of the hardcover 2nd edition 1998 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. production: PRO EDIT GmbH, Heidelberg Illustrations: G. Hippmann, Niirnberg Typesetting (Data conversion): K+V Fotosatz GmbH, Beerfelden Cover-Design: E. Kirchner, Heidelberg SPIN 10566757

13/3135-5 4 3 2 1 0 - Printed on acid-free paper

Preface

The first edition of "Testosterone: Action, Deficiency, Substitution" was published in 1990. Since then our understanding of the hormone that turns males into men has