Textbook of Coronary Thrombosis and Thrombolysis

Teleologically, the hemostatic mechanism is among The of Coronary Thrombosis and the most fundamental yet complex physiologic pro- in essence, represents a heartfelt gift of cesses in humans. Early scientists and physicians were knowledge from a dedicated

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Developments in Cardiovascular Medicine M.LeWinter. H. Suga and M.W. Watkins (eds.): Cardiac Energetics: From Emax to Pressure-volume Area. 1995 ISBN 0-7923-3721-2 ISBN 0-7923-3722-0 R.J. Siegel (ed.): Ultrasound Angioplasty. 1995 D.M. Yellon and G.J. Gross (eds.): Myocardial Protectionand the Katp Channel. 1995 ISBN 0-7923-3791-3 A.V.G. Bruschke. J.H.C. Reiber. K.I. Lie and H.j.j. Wellens (eds.): Lipid Lowering Therapy and Progression of Coronary Atherosclerosis. 1996 ISBN 0-7923-3807-3 A.S.A. Abd-Elfattah and A.S. Wechsler (eds.): Purines and Myocardial Protection. 1995 ISBN 0-7923-3831-6 M. Morad, S. Ebashi, W. Trautwein and Y. Kurachi (eds.): Molecular Physiology and Pharmacology of Cardiac ton Channels and Transporters. 1996 ISBN 0-7923-3913-4 A.M. Oto (ed.): Practiceand Progress in Cardiac Pacing and Electrophysiology. 1996 ISBN 0-7923-3950-9 W.H. Birkenhager (ed.): Practical Management of Hypertension. SecondEdition. 1996 ISBN 0-7923-3952-5 J.C. Chatham, J.R. Forder and J.H. McNeill (eds.): The Heart In Diabetes. 1996 ISBN 0-7923-4052-3 M. Kroll, M. Lehmann (eds.): Implantable CardioverterDefibrillator Therapy: The Engineering-Clinical Interface. 1996 ISBN 0-7923-4300-X Lloyd Klein (ed.): Coronary Stenosis Morphology: Analysis and Implication. 1996 ISBN 0-7923-9867-X Johan H.C. Reiber, Ernst E. Van der Wall (eds.): Cardiovascular Imaging. 1996 ISBN 0-7923-4109-0 ISBN 0-7923-4143-0 A.-M. Salmasi, A. Strano (eds.): Angiology in Practice. Julio E. Perez, Roberto M. Lang, (eds.): Echocardiography and Cardiovascular Function: Toolsfor the Next Decade. 1996 ISBN 0-7923-9884-X Keith L. March (ed.): Gene Transfer in the Cardiovascular System: ExperimentalApproaches and Therapeutic Implications. 1997 ISBN 0-7923-9859-9 Anne A. Knowlton (ed.): Heat Shock Proteinsand the Cardiovascular System. 1997 ISBN 0-7923-9910-2 Richard C. Becker (ed.): Textbook of Coronary Thrombosis and Thrombolysis. 1997 ISBN 0-7923-9923-4

T E X T B O O K OF CORONARY THROMBOSIS A N D THROMBOLYSIS Edited by

Richard C. Becket, M.D. Director, Cardiovascular Thrombosis Research Center Director, Coronary Care Unit University of Massachusetts Medical School Worcester, Massachusetts

Kluwer Academic Publishers BOSTON DORDRECHT LONDON

DISTRIBUTORS For North America: Kluwer Academic Publishers 101 Philip Drive Norwell, Massachusetts 02061 USA For all other countries: Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 A H Dordrecht, THE N E T H E R L A N D S

Library of Congress Cataloging-in-Publication Data Textbook of coronary thrombosis and thrombolysis / edited by Richard C. Becker. p. cm. -- (Developments in cardiovascular medicine) Includes index. ISBN 0-7923-99234 (alk. paper) 1. Coronary heart disease. 2. Thrombosis. 3. Thrombolytic therapy. I. Becker, Richard C. II. Series. [DNLM: 1. Coronary Thrombosis--drug therapy. 2. Myocardial Infarction--drug therapy. 3. Thrombolytic Therapy. 4. Fibrinolytic Agents-therapeutic use. WG 300 T355 1997] RC685.C6T375 1997 616.1'23--dc21 DNLM/DLC for Library of Congress 97-16368