The association between albuminuria and thyroid antibodies in newly diagnosed type 2 diabetes mellitus patients with Has
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RESEARCH ARTICLE
Open Access
The association between albuminuria and thyroid antibodies in newly diagnosed type 2 diabetes mellitus patients with Hashimoto’s thyroiditis and euthyroidism Wei Zhu1,2, Xuejie Dong2, Qingrong Pan1, Yanjin Hu1 and Guang Wang1*
Abstract Background: Microalbuminuria is a prognostic marker of diabetes kidney disease. It is generally diagnosed as the ratio of urinary albumin to creatinine (UACR) of 30-300 mg/g. Hashimoto’s thyroiditis is a common disease in the endocrinology and the thyroid antibodies may associated with kidney disease. We investigated the UACR in the newly diagnosed T2DM with Hashimoto’s thyroiditis and tried to detect the relationship between the UACR and thyroid antibodies. Methods: One hundred twenty newly diagnosed T2DM patients with Hashimoto’s thyroiditis and euthyroidism and 50 sex and age-matched T2DM with non-Hashimoto’s and other thyroid disease were recruited. T2DM patients were divided into 2 groups by the titer of TPOAb: (1). TPOAb (+) group: T2DM with positive TPOAb (n = 105); (2). TPOAb (−) group: T2DM with negative TPOAb (n = 65). Results: T2DM with positive TPOAb group had higher UACR than T2DM with negative TPOAb group (21.55 ± 7.28 vs 15.13 ± 5.69 mg/g, P < 0.01). UACR were positively related to BMI (r = 0.255, P < 0.05), FPG (r = 0.285, P < 0.05), HbA1c (r = 0.260, P < 0.05) and TPOAb (r = 0.349, P < 0.05). HbA1c (β = 0.793, P < 0.05), BMI (β = 0.342, P < 0.05) and lnTPOAb (β = 1.207, P < 0.05) were independently associated with UACR. Conclusions: In the newly diagnosed T2DM patients, Hashimoto’s thyroiditis with TPOAb positive had higher UACR levels. TPOAb titer, BMI and HbA1c were independent associated with UACR in these patients. Keywords: Type 2 diabetes mellitus, Hashimoto’s thyroiditis, Microalbuminuria
Background Type 2 diabetes mellitus (T2DM) is an important public health problem in the world and 10.9% of the adult population in China was affected in 2013 [1]. Microalbuminuria is generally diagnosed as the ratio of urinary albumin to creatinine (UACR) of 30-300 mg/g or urine albumin excretion of 30-300 mg/24 h [2]. Microalbuminuria is a * Correspondence: [email protected] 1 Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China Full list of author information is available at the end of the article
prognostic marker of diabetes kidney disease [3]. In addition, microalbuminuria increased the risk of cardiovascular morbidity and mortality, stroke, and heart failure. It begins even when the microalbuminuria is in normal range or high-normal range in both diabetes and euglycemic individuals [4–6]. For the diabetes patients, American diabetes association suggested that the urinary albumin should be assessed at least once per year [7]. Hashimoto’s thyroiditis is another common disease in the endocrinology. The morbidity of Hashimoto’s thyroiditis is 0.2% in men and 2% in women [8]. It is an
© The Author(s). 2020 Open Access This article is licensed under a Creative Commons
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