The Cadherin Superfamily Key Regulators of Animal Development and Ph
This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become cl
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Cadherin Superfamily Key Regulators of Animal Development and Physiology
The Cadherin Superfamily
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Shintaro T. Suzuki • Shinji Hirano Editors
The Cadherin Superfamily Key Regulators of Animal Development and Physiology
Editors Shintaro T. Suzuki Department of Bioscience Kwansei Gakuin University Sanda Hyogo, Japan
Shinji Hirano Department of Cell Biology Kansai Medical University Hirakata Osaka, Japan
ISBN 978-4-431-56031-9 ISBN 978-4-431-56033-3 DOI 10.1007/978-4-431-56033-3
(eBook)
Library of Congress Control Number: 2016939963 © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK
Foreword
Intercellular interactions are prime determinants of the form and function of tissues in all multicellular organisms. It is therefore no wonder that searching for the molecular bases of these interactions has preoccupied developmental and cell biologists for over a half-century. Classical embryological experiments during the 1950s and 1960s by pioneers such as Holtfreter, Moscona, Sperry, and Steinberg led to the idea of selective affinities among cells as a major driving force in morphogenesis. Their compelling hypotheses motivated initial attempts to isolate “adhesion molecules” by the next generation of biochemists, including Glaser, Gottlieb, Lilien, Marchase, Roseman, and Steinberg (Gottlieb and Glaser 1980). Sadly, these forays fared poorly: biochemical methods of the time were inadequate to deal with molecules embedded in membranes and present in small amounts. Then, suddenly, everything changed. In 1977, Masatoshi Takeichi demonstrated that cells bear two adhesion systems, calcium-dependent and calcium-independent, and that calcium protects the calcium-dependent adhesion molecule from proteolysis (Takeichi 1977). His critical insights suggested a strategy for purifying the adhesion molecules, and within
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