The correlation between striatal and cortical binding ratio of 11 C-PiB-PET in amyloid-uptake-positive patients
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ORIGINAL ARTICLE
The correlation between striatal and cortical binding ratio of 11C-PiBPET in amyloid-uptake-positive patients Julia Sauerbeck1,2 · Kazunari Ishii1,3,4 · Chisa Hosokawa1,4 · Hayato Kaida1 · Franziska T. Scheiwein1,2 · Kohei Hanaoka4 · Axel Rominger2 · Matthias Brendel2 · Peter Bartenstein2 · Takamichi Murakami1 Received: 29 January 2018 / Accepted: 17 April 2018 © The Japanese Society of Nuclear Medicine 2018
Abstract Purpose In subjects with amyloid deposition, striatal accumulation of 11C-Pittsburgh compound B (PiB) demonstrated by positron emission tomography (PET) is related to the stage of Alzheimer’s disease (AD). In this study, we investigated the correlation between striatal and cortical non-displaceable binding potential (BPND). Methods Seventy-three subjects who complained of cognitive disturbance underwent dynamic PiB-PET studies and showed positive PiB accumulation were retrospectively selected. These subjects included 34 AD, 26 mild cognitive impairment, 2 frontotemporal lobar degeneration, 2 Parkinson’s disease, 5 dementia with Lewy bodies, and 4 undefined diagnosis patients. Individual BPND images were produced from the dynamic data of the PiB-PET study, and voxel-based analyses were performed to estimate the correlations between striatal and other regional cortical BPND measures. Results There were highly significant correlations between striatal and prefrontal BPND, with the highest correlation being demonstrated in left Brodmann area 11. We found that almost all of the high cortical BPND values correlated with striatal BPND values, with the exception of the occipital cortex with low correlation. Conclusion Our study demonstrated positive correlations in amyloid deposits between the striatum and other cortical areas with functional and anatomical links. The amyloid distribution in the brain is not random, but spreads following the functional and anatomical connections. Keywords Dementia · Alzheimer’s disease · 11C-PiB-PET · FDG-PET · Amyloid deposit · Striatum
Introduction In this time of ageing populations, the number of patients with Alzheimer’s disease (AD) and dementia is increasing, with a global total of 35.6 million in 2010, which is forecast * Kazunari Ishii [email protected] 1
Department of Radiology, Kindai University Faculty of Medicine, 377‑2 Ohnohigashi, Osakasayama, Osaka 589‑8511, Japan
2
Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany
3
Neurocognitive Disorders Center, Kindai University Hospital, Osakasayama, Osaka, Japan
4
Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University, Osakasayama, Osaka, Japan
to reach 66 million by 2030 [1]. As this implies an enormous burden on health care systems, much effort has been put into research on the pathophysiology of AD. It is known that AD is characterized by the presence of amyloid plaques and neurofibrillary tangles, as well as the significant loss of neurons [2–4]. To detect the pathology of AD, amyloid i
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