The effect of parental age on NF1 patients in Turkey
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ORIGINAL ARTICLE
The effect of parental age on NF1 patients in Turkey P. Sharafi 1 & B. Anlar 2 & S. Ersoy-Evans 3 & A. Varan 4 & O. F. Yılmaz 5 & M. Turan 5 & S. Ayter 1
Received: 20 March 2017 / Accepted: 7 November 2017 # Springer-Verlag GmbH Germany, part of Springer Nature 2017
Abstract Neurofibromatosis type 1 (NF1) is the most common neurogenetic disorder worldwide, and its clinical presentations are highly variable. NF1 is caused by mutations in the NF1 gene, and 50% of NF1 cases are sporadic, which occur in the absence of a family history of the disease and usually result from a new mutation in the germline of a parent. Advanced paternal age may increase the risk for germinal NF1 mutations; however, some dominant conditions, including neurofibromatosis, have shown a lesser association with paternal age, although there are conflicting reports in the literature. We investigated the effects of paternal and maternal age in 241 NF1 patients (121 sporadic and 120 familial cases) who were seen in Hacettepe hospital, a reference center for genetic diseases in Turkey. For statistical analysis, Spearman’s and Chi-square tests were used. In this study, we evaluated paternal and maternal age at birth in sporadic and familial cases of NF1. We also compared the effect of parental age on the appearance and coexistence of various NF1 symptoms. There were no significant statistical differences between paternal age and coexistence of the NF1 symptoms. However, a slightly negative
correlation was observed between paternal age and the coexistence of NF1 symptoms in familial cases (p < 0.05). We did not find strong evidence for the effect of parental age on the clinical severity of NF1. Keywords Neurofibromatosis type 1 . Advanced paternal age . Advanced maternal age . Spontaneous mutations
Introduction Neurofibromatosis type 1 (NF1) is the most common neurogenetic disorder which affects 1 in 3000–3500 individuals worldwide (Rasmussen and Friedman 2000). The clinical presentation of NF1 is highly variable (Friedman 1999; Williams et al. 2009); some typical appearances are cafe-au lait spots, frecklings, malignant peripheral nerve sheath tumors (MPNST; neurofibromas as a benign form and neurofibrosarcomas as a malignant form), and other malignancies, such as intracranial astrocytomas, gastrointestinal stromal tumors, pheochromocyto-
* S. Ayter [email protected]
M. Turan [email protected]
P. Sharafi [email protected]
1
B. Anlar [email protected]
Department of Medical Biology, TOBB University of Economics and Technology, Faculty of Medicine, Ankara, Turkey
2
Department of Pediatrics, Pediatric Neurology, Hacettepe University, School of Medicine, Ankara, Turkey
3
Department of Dermatology, Hacettepe University, School of Medicine, Ankara, Turkey
A. Varan [email protected]
4
Department of Pediatrics, Pediatric Oncology, Hacettepe University, School of Medicine, Ankara, Turkey
O. F. Yılmaz [email protected]
5
Faculty of Medicine, TOBB University of Economics and Technology, Ankara, Turkey
S. Erso
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