The Forgotten Cure The Past and Future of Phage Therapy
“Bacteriophages have the potential to stop many if not most life threatening, drug resistant bacterial infections. The Forgotten Cure is a non-stop, cover to cover read.” James D. Watson, Nobel Laureate “A lively tale of killer viruses, s
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Anna Kuchment
The Forgotten Cure The Past and Future of Phage Therapy
Anna Kuchment Editor, Advances Scientific American New York, NY 10013, USA [email protected]
© Springer Science+Business Media, LLC 2012 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Published in the United States by Copernicus Books, an imprint of Springer Science+Business Media. Copernicus Books Springer Science+Business Media 233 Spring Street New York, NY 10013 www.springer.com Library of Congress Control Number: 2011940296 Manufactured in the United States of America. Printed on acid-free paper ISBN 978-1-4614-0250-3 e-ISBN 978-1-4614-0251-0 DOI 10.1007/978-1-4614-0251-0
For Mark, Eliza and my parents.
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Acknowledgments
I’d like to thank, first and foremost, my sources: the scientists and entrepreneurs who trusted their life’s work to me and sat by patiently as the book wound its way through the reporting, writing and publishing process. I’m also grateful to my production editor at Copernicus Books, Arthur Smilios, to my agent Gary Morris, and to my first editor, Paul Farrell, who acquired the project. George Hackett, my former editor at Newsweek, carefully read and edited the final draft. This book would never have come into being were it not for Fred Guterl, my science editor at Newsweek International, who first assigned me a story on phage therapy in 2001. A large cast of former and current colleagues allowed me to take time off to work on this book over the years and also filled in for me while I was out. These include: Michael Elliott, Alexis Gelber, Fareed Zakaria, Steven Strasser, Nisid Hajari, Adam Piore, David Stone, Brian Connolly, and John Tucker. Jerry Adler, Sam Freedman, Claudia Kalb, Shannon Jones, Allegra Wechsler, Anne Underwood, Karen Springen, and Will Dobson provided important encouragement along the way. Andy Nagorski was indispensable when it came to logistics and overseas reporting advice. Mark Ptashne took time to read a draft of the book and helped me address some of its early shortcomings. For research help, the Archives of the Pasteur Institute, the Newsweek Research Center, the Los Angeles Times Library, and the Tom Mix Museum were incredibly generous and supportive. The Columbia University policy of allowing its alumni virtually free access to Butler Library is a boon that made researching and writing this book a true pleasure. I may never have finished this book were it not for Ilyon Woo, who sets a high bar when it comes to talent, time management and determination. Her example, combined with her encouragement and outright nagging, kept me from giving up on the project. My parents, who, like me, come from the part of the world where phages are still in use, were the inspiration for this book. My aunt and uncle, Sophie Vilker and Adriaan Jobse, asked often about its
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