The impact of diabetes mellitus and other chronic medical conditions on health-related Quality of Life: Is the whole gre
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The impact of diabetes mellitus and other chronic medical conditions on health-related Quality of Life: Is the whole greater than the sum of its parts? Hwee-Lin Wee1,2, Yin-Bun Cheung3, Shu-Chuen Li1, Kok-Yong Fong2,4 and Julian Thumboo*2,4 Address: 1Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Republic of Singapore, 2Department of Rheumatology and Immunology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore, 3National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Republic of Singapore and 4Department of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Republic of Singapore Email: Hwee-Lin Wee - [email protected]; Yin-Bun Cheung - [email protected]; Shu-Chuen Li - [email protected]; KokYong Fong - [email protected]; Julian Thumboo* - [email protected] * Corresponding author
Published: 12 January 2005 Health and Quality of Life Outcomes 2005, 3:2
doi:10.1186/1477-7525-3-2
Received: 03 August 2004 Accepted: 12 January 2005
This article is available from: http://www.hqlo.com/content/3/1/2 © 2005 Wee et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Diabetes mellitus (DM) is an important public health concern, the impact of which is increased by the high prevalence of co-existing chronic medical conditions among subjects with DM. The aims of this study were therefore to (1) evaluate the impact of DM and co-existing chronic medical conditions on health-related quality of life (HRQoL) (which could be additive, synergistic or subtractive); (2) to determine the extent to which the SF-6D (a single-index preference measure) captures the multidimensional information provided by the SF-36 (a profile measure). Methods: Using data from a cross-sectional, population-based survey of Chinese, Malay and Indians in Singapore, we developed 9 separate multiple linear regression models, with each SF-36 scale or SF-6D index score being the dependent variable for one model. The influence of DM and a second chronic medical condition (hypertension (HTN), heart disease (HD), musculoskeletal illnesses (MS)) and their interactions were studied after adjusting for the influence of potential confounding variables. Results: Among 5,224 subjects, the prevalence of DM, HTN, HD and MS were 5.9%, 10.7%, 2.4% and 26.6% respectively. DM lowered SF-36 scores by more than 2 points on 3 SF-36 scales and lowered SF6D scores by 0.03 points. Subjects with DM and HTN, DM and HD or DM and MS experienced further lowering of SF-36 scores exceeding 2 points on at least 6 scales and further lowering of SF-6D scores by 0.05, 0.08 and 0.10 points respectively. Generally, DM and co-existing medical conditions exerted addi
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