The impact of hybrid contact lenses on keratoconus progression after accelerated transepithelial corneal cross-linking

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ORIGINAL PAPER

The impact of hybrid contact lenses on keratoconus progression after accelerated transepithelial corneal crosslinking Mehmet Go¨khan Aslan . Hu¨seyin Fındık Emre Aydın . Feyzahan Uzun

. Murat Okutucu

.

Received: 6 May 2020 / Accepted: 16 August 2020 Ó Springer Nature B.V. 2020

Abstract Purpose To investigate the effect of hybrid contact lenses (HCLs) on keratoconus (KCN) progression after accelerated transepithelial cross-linking (A-TE CXL). Methods Thirty-five eyes of 26 patients who preferred Ultrahealth HCLs for an optical correction after A-TE CXL formed the study group, and 45 eyes of 34 patients who preferred spectacle correction were ageand sex-matched to form the control group. Corrected distance visual acuity (CDVA), maximum keratometry, mean keratometry, apical posterior keratometry, cylindrical power, minimum corneal thickness, keratoconus vertex indices and curvature asymmetry indices obtained by Scheimpflug corneal topography were compared before, 6 and 12 months after the procedure. Anterior segment optic coherence tomography (AS-OCT) was performed to measure the apical corneal clearance of HCL-wearing patients. Results The median pre-CXL CDVA value of the patients in the HCL group was logMAR 0.30 (0.20–1.0), and it was logMAR 0.30 (0.10–1.0) in the spectacle-corrected group. There was a significant increase in CDVA 6 and 12 months after CXL

M. G. Aslan (&)  H. Fındık  M. Okutucu  E. Aydın  F. Uzun Department of Ophthalmology, Recep Tayyip Erdogan University Medical Faculty, Islampasa Mah, 53020 Merkez, Rize, Turkey e-mail: [email protected]

procedure in both groups (p \ 0.001, 0.003, respectively). The median front curve asymmetry index (FCAsym) significantly improved after A-TE CXL in the HCL group. The pre-CXL and 12th-month topographic comparisons of the spectacle-corrected group revealed no significant difference. In addition, no significant difference was observed between topographic alterations of two groups (p [ 0.05). Conclusion The CDVA significantly improved, and KCN progression was halted in patients wearing HCL 12 months after A-TE CXL. Besides, FCAsym indices can be considered for follow-up of the HCL-wearing patients as an assistive parameter to AS-OCT measurements. Keywords Accelerated transepithelial corneal cross-linking  Corneal topography  Hybrid contact lens  Keratoconus

Introduction Keratoconus (KCN) is characterized by progressive protrusion of cornea that leads to irregular astigmatism [1]. Currently, the only treatment to stop the progression and to recede the disease is corneal collagen cross-linking (CXL) which provides improvements both in visual acuity and topographic parameters [2, 3].

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Int Ophthalmol

Several non-surgical options are available for the refractive correction of KCN patients. Glasses and soft contact lenses (CLs) are used in the early stages of the disease. However, more advanced cases require rigid gas permeable (RGP), piggyback, hybrid and scleral CLs to obtai