The Kidney in Pregnancy

The behavior of the kidney in normal pregnancy, as well as in complicated pregnancy, is a very interesting, but still in many ways an unknown topic in renal medicine. It is undoubtedly difficult to determine, even in normal women, the behavior of renal he

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TOPICS IN RENAL MEDICINE Vittorio E. Andreucci, Series Editor

THE KIDNEY IN PREGNANCY

EDITED BY VITTORIO E. ANDREUCCI

MARTINUS NIJHOFF PUBLISHING A MEMBER OF THE KLUWER ACADEMIC PUBLISHERS GROUP BOSTON

DORDRECHT

LANCASTER

Copyright 1986 © by Martinus Nijholf Publishing, Boston Softcover reprint of the hardcover 1st edition 1986 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without written permission of the publisher, Martinus Nijholf Publishing, 190 Old Derby Street, Hingham, Massachusetts 02043. Distributors

for the United States and Canada: Kluwer Academic Publishers, 190 Old Derby Street, Hingham, MA, 02043, USA for the UK and Ireland: Kluwer Academic Publishers, MTP Press Limited, Falcon House, Queen Square, Lancaster LAl 1RN, UK for all other countries: Kluwer Academic Publishers Group, Distribution Centre, P.O. Box 322, 3300 AH Dordrecht, The Netherlands

Library of Congress Cataloging in Publication Data Main entry under title: The Kidney in pregnancy. (Topics in renal medicine) 1. Pregnancy, Complications of. 2. KidneysDiseases. I. Andreucci, Vittorio E. I. Series. [DNLM: 1. Kidney-physiology. 2. Kidney-physiopathology. 3. Pregnancy Complications. WJ 301 K46] RG580.K5K523 1985 618.3 85-11437 ISBN-13 : 978-1-4612-9638-6 001: 10.1007/978-1-4613-2619-9

e-ISBN-13 : 978-1-4613-2619-9

To my mother, wife, and daughter and to all pregnant and nonpregnant women

CONTENTS

Contributing Authors IX List of Abbreviations xv Preface XVll 1. Renal hemodynamics in pregnancy

1

ANTONIO DAL CANTON, VITTORIO E. ANDREUCCI

2. Pathogenesis of preeclampsia

13

GINA GREGORINI, NORBERTO PERICO, GIUSEPPE REMUZZI

3. Coagulation and pregnancy

35

EDOARDO ROSSI, MARIA MATILDE COSSU, PIERO CAPETTA

4. Pathology of the kidney in preeclampsia

47

JAMES R. TAYLOR, BENJAMIN H. SPARGO

5. Renal function during normal pregnancy and the effect of renal disease and preeclampsia 65 JOHN M. DAVISON

6. Sodium metabolism in normal pregnancy and in preeclampsia

81

WOLFRAM E. NOLTEN, EDWARD N. EHRLICH

7. Hypertension complicating pregnancy

95

NORMAN F. GANT, JACK A. PRITCHARD

8. Treatment of chronic hypertension in pregnancy

123

VITTORIO E. ANDREUCCI, ANTONIO DAL CANTON, DOMENICO RUSSO

vii

viii

Contents

9. Proteinuria during pregnancy

133

PRISCILLA S. KINCAID-SMITH, ROBYN A. NORTH, GAVIN J. BECKER, KENNETH F. FAIRLEY

10. Acute renal failure in pregnancy

165

..

NATHALIE PERTUISET, DOMINIQUE GANEVAL, JEAN-PIERRE GRUNFELD

11. Successful pregnancies in women on regular dialysis treatment and women with a functioning transplant 185 SABRI CHALLAH, ANTONY J. WING, MICHEL BROYER, GIANFRANCO RIZZONI

12. Pregnancy following renal transplantation ISRAEL PENN

13. Urinary tract infection in pregnancy lAIN R. MCFADYEN

Index

231

205

195

Contributing Authors

Vittorio E. Andreucci, MD Professor of Nephrology and Chairman, Department of Nephrology Second Faculty of Medicine