Total Tumor Volume Should be Considered as an Important Prognostic Factor for Synchronous Multiple Gastric Cancer Patien
- PDF / 535,742 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 29 Downloads / 180 Views
ORIGINAL ARTICLE
Total Tumor Volume Should be Considered as an Important Prognostic Factor for Synchronous Multiple Gastric Cancer Patients with Curative Gastrectomy Xiaolong Tang 1 & Qingsi He 1 & Guorui Sun 1 & Hui Qu 1 & Jia Liu 2 & Lei Gao 3 & Jingbo Shi 3 & Jianhong Ye 3 & Yahang Liang 3 Received: 29 April 2019 / Accepted: 4 March 2020 # Arányi Lajos Foundation 2020
Abstract Synchronous multiple gastric cancer (SMGC) was a special type of gastric cancer with relatively low incidence. This article was designed to demonstrate that the total tumor volume (TTV) should be treated as an important prognostic factor in SMGC patients with curative gastrectomy. This study retrospective analyzed 140 SMGC patients who received curative gastrectomy between December 2004 and December 2014 in our hospital. Clinicopathological features, preoperative evaluation, surgical treatment, and outcome parameters were reviewed and analyzed. This study applied univariate and multivariate analyses to identify the most significant prognostic factors. In the univariate analysis, the TTV, pTTVNM, pN stage, pT of main tumor were all significant prognostic factors in SMGC patients (all P < 0.05). In the multivariate analysis, pN stage, TTV and pTTVNM were confirmed to be independent prognostic factors (all P < 0.05). In the comparison of survival analysis, the pTTVNM stage system (P < 0.05) was superior to the pTNM stage system (P > 0.05) in SMGC patients. In conclusion, the TTV should be considered as an independent prognostic factor in overall survival in SMGC patients who received curative gastrectomy. The pTTVNM stage should be recommended as a suitable staging system for SMGC patients. Keywords Gastric cancer . Tumor volume . Gastrectomy . Prognosis
Abbreviations SMGC Synchronous multiple gastric cancer TTV Total tumor volume GC Gastric cancer AJCC American Joint Committee on Cancer UICC Union of International Cancer Control TNM Tumor-node-metastasis TV Tumor volume
* Guorui Sun [email protected] 1
Department of General Surgery, Qilu Hospital of Shandong University, No.107, West of Wenhua Street, Lixia District, 250012 Jinan, China
2
Department of Health Management Center, Qilu Hospital of Shandong University, 250012 Jinan, China
3
Qilu Medical College of Shandong University, 250011 Jinan, Shandong, China
Introduction Gastric cancer (GC) is the second leading cancer in the world, and the prognosis of advanced GC remains poor [1]. Synchronous multiple gastric cancer (SMGC) was a special type of gastric cancer. In previous studies, the incidence of SMGCs was reported to be 5–10% [2]. The criteria for SMGCs were defined as follows: (1) each tumor must be histopathologic confirmed by pathology reports; (2) tumors are separated from each other in the stomach; (3) no tumor is result from extension or metastasis of another tumor [3]. In recent years, the American Joint Committee on Cancer (AJCC)/ Union of International Cancer Control (UICC) tumor-node-metastasis (TNM) staging system was widely used in gastric cancer. However, in pat
Data Loading...
