Towards refining the definition of grey zone for late gadolinium enhancement
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BioMed Central
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Poster presentation
Towards refining the definition of grey zone for late gadolinium enhancement Dana C Peters*, Yuchi Han, Evan A Appelbaum, Reza Nezafat, Beth Goddu, Kraig V Kissinger, Warren J Manning and Jaime L Shaw Address: Beth Israel Deaconess Medical Center, Boston, MA, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P159
doi:10.1186/1532-429X-12-S1-P159
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P159 © 2010 Peters et al; licensee BioMed Central Ltd.
Introduction Grey zone on late gadolinium enhancement images (LGE) is quantified using signal intensity (SI) (1,2). However, LGE signal depends on heart-rate and TI choice, and the noise.
(age 36 ± 19 years), 20-25 minutes after 0.2 mmol/kg injection of Gd-DTPA. A two-parameter non-linear leastsquares fit was applied to the data in Matlab.
Purpose To demonstrate that grey zone and scar quantified on LGE depend on image SNR and inversion time (TI), and to use T1-mapping to assess the normal range of post-contrast T1 values in the heart, for improved detection of grey zone.
Methods Phantom studies A collection of phantoms (505-302 ms T1s, in 50 ms increments) with known T1s were imaged using LGE sequences, with scan parameters: 1RR between inversions, TR/TE/θ = 5.7 ms/3.4 ms/20º, 1.5 × 1.5 × 5 mm, 20 viewsper-segment, sequential order. The phantom with T1 = 505 ms represented "normal myocardium" and the phantom with T1 = 302 ms represented "scar". The myocardial signal was nulled, and scar and grey zone thresholds were calculated using 50% of maximal SI (2) in scar and maximal SI in the "normal myocardium" (2). The LGE sequence was acquired at higher SNR, and at optimal TI and optimal TI ± 30 ms. T1 mapping An ECG-gated T1 map was obtained using the LGE multiple TI approach (3) in 3 healthy subjects and one patient
between For usingLGE Figure SI 1 based images T1 values definitions, with andvaried scarusing and SNRphantom grey and zone nulling, study cutoffs the relationship is shown For LGE images with varied SNR and nulling, the relationship between T1 values and scar and grey zone cutoffs is shown using SI based definitions, using phantom study. "REF" the standard optimally nulled image. SNR was increased by averaging ("2X SNR").
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Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P159
http://jcmr-online.com/content/12/S1/P159
Figure 2 Representative T1 map in a health subject post contrast Representative T1 map in a health subject post contrast.
Results Phantoms studies Figure 1 shows the T1s ranges included as "scar" and "grey zone" using the applied
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