Tranexamic acid: a simple way to reduce drainage and bleeding in rhytidoplasty
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ORIGINAL PAPER
Tranexamic acid: a simple way to reduce drainage and bleeding in rhytidoplasty Hector Mauricio Serrano Reyes 1 & Joaquin Ramirez 1 & Hugo Aguilar Villa 1 & Juan Pablo Arbelaez 1 & Walter Morrou 1 & Marcelo Aniceto 1 & Francesco Mazzarone 1 Received: 12 June 2020 / Accepted: 26 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Hematoma is the most common complication in facelift surgery. It has a reported incidence ranging from 0.2 to 8%. Tranexamic acid (TXA) is an antifibrinolytic agent capable of minimizing blood loss, and its use in plastic surgery is quite new. The literature review indicates that there are no formal guidelines for dosing and standardization of TXA use. We sought to evaluate the efficacy of intraoperative local irrigation of TXA in reducing the incidence of hematomas in patients undergoing facelift surgery. Methods A prospective cohort observational comparative study was conducted between November 2018 and November 2019 with 30 patients undergoing primary facelift surgery at the Ivo Pitanguy Institute in Rio de Janeiro, Brazil. The participants were divided into two groups: group I, patients who underwent facelift with 2.5% topical TXA irrigation as a new routine of the service, and group II, patients who underwent facelift without topical TXA irrigation as a routine. Results Drainage output in the first 24 h, hematoma formation, and complication rate were evaluated. It was found that local intraoperative TXA irrigation reduces drainage output in the first 24 h by 71% compared with group II (median 10 ml (8–22 ml) versus 35 ml (19–50 ml); p = 0·009). The rate of postoperative complications (p = 0.1) and hematoma (p = 0.08) was lower in the group with intraoperative local irrigation with TXA. This was not statistically significant. Conclusion Local TXA irrigation seems to decrease bleeding and has been shown to be effective in reducing drainage output in the first 24 h postoperatively. Level of evidence: Level III, risk / prognostic study. Keywords Facelift . Hematoma . Complications . Tranexamic acid
Introduction Facial rejuvenation and neck contouring procedures are one of the most commonly performed cosmetic surgeries worldwide [1–3]. An extensive variety of rhytidoplasty techniques have Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00238-020-01735-8) contains supplementary material, which is available to authorized users. * Hector Mauricio Serrano Reyes [email protected] 1
Department of Plastic Surgery, Instituto Ivo Pitanguy, Rua Santa Luzia, 206, Rio de Janeiro, Rio de Janeiro 20020022, Brazil
been described mainly based on differences on the extension of the dissection of the flap, dissection plane, treatment of the superficial musculo-aponeurotic system (SMAS), liposuction of the jowl, and repositioning of the malar fat pad [4]. Hematoma is the most frequent complication in facelift surgery [4–7]. Its occurrence can threaten the viability of the skin flaps and can delay surgical
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