Transesophageal echocardiography in swine: evaluation of left and right ventricular structure, function and myocardial w
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ORIGINAL PAPER
Transesophageal echocardiography in swine: evaluation of left and right ventricular structure, function and myocardial work Sebastian Billig1 · Rashad Zayat2 · Andreas Ebeling1 · Henning Steffen2 · Christoph Nix1,3 · Nima Hatam2 · Heike Schnöring2 · Matthias Derwall1 Received: 11 July 2020 / Accepted: 29 September 2020 © The Author(s) 2020
Abstract This study aimed to determine standard left (LV) and right ventricular (RV) transesophageal echocardiographic (TEE) measurements in swine. Additionally, global myocardial work index (GWI) was estimated using pressure-strain loops (PSL). A comprehensive TEE examination was conducted in ten anesthetized, intubated and mechanically ventilated healthy female German landrace swine, weighing 44 to 57 kg. For GWI calculation, we performed LV and RV segmental strain analysis and used invasively measured LV and RV pressure to obtain PSL. The GWI and further myocardial work indices were calculated from the area of the PSL using commercially available software. Furthermore, hemodynamic measurements were obtained using indwelling catheters. We obtained complete standardized baseline values for left and right ventricular dimensions and function. Biplane LV ejection fraction was 63 ± 7 % and the LV end-diastolic volume was 70.5 ± 5.9 ml. Tissue Doppler estimated peak tricuspid annular systolic velocity was 13.1 ± 1.8 cm/s. The Doppler estimated LV and RV stroke volume index were 75.6 ± 7.2 ml/m2 and 76.7 ± 7.8 ml/m2 respectively. Pulsed wave Doppler derived cardiac output correlated well with cardiac output estimated using the thermodilution method (7.0 ± 1.2 l/min vs. 7.0 ± 1.1 l/min, r = 0.812, p = 0.004). The LV global longitudinal strain was -21.3 ± 3.9 % and the RV global longitudinal strain was -15.4 ± 2.5 %. LV GWI was 1885(1281–2121) mmHg*% and 297 ± 62 mmHg*% for the RV. LV global myocardial work efficiency was 82.6 ± 4 % and 83(72–88) % for the RV. TEE offers sufficient morphological, functional and hemodynamic assessment of the heart in swine. Myocardial contractility and mechanics can be reliably evaluated with the non-invasive GWI derived from echocardiography without additional invasive measures. Keywords Transesophageal echocardiography · Non-invasive hemodynamic monitoring · Speckle tracking · Myocardial work · Myocardial contractility · Swine model
Introduction
Sebastian Billig, Rashad Zayat, Heike Schnöring and Matthias Derwall have contributed equally to this work. * Matthias Derwall [email protected] 1
University Hospital RWTH Aachen, Department of Anesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen 52074, Germany
2
University Hospital RWTH Aachen, Department of Thoracic and Cardiovascular Surgery, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, Aachen 52074, Germany
3
Abiomed Europe GmbH, Neuenhofer Weg 3, Aachen 52074, Germany
Echocardiography is an invaluable diagnostic tool for analysis of cardiac anatomy and function [1, 2]. Therefore, it is widely used in daily clinical routine as wel
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