Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome
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LETTER TO THE EDITOR
Open Access
Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome Anca Chiriac1,2,3, Adrian Naznean4, Cristian Podoleanu5*
and Simona Stolnicu6
Abstract A differential diagnosis must be made between transient yellow discoloration of the nails and yellow nail syndrome. We highlight some practical aspects of yellow nail discoloration. Keywords: Yellow nail syndrome, Yellow discoloration, Nail Sir, We read with great interest the article by Vignes et al. recently published by the journal [1]. We would like to add some practical issues related to differential diagnosis of yellow nail discoloration. A differential diagnosis must be made between transient yellow discoloration of the nails and yellow nail syndrome. Yellow discoloration of the nails has been reported as an adverse reaction after some drugs such as: quinaqrine used for cutaneous lupus erythematosus [2], after topical use of 5-fluorouracil for the treatment of nail psoriasis (Fig. 1) [3], temsirolimus [4], or bucillamine for rheumatoid arthritis [5], retinoids [6] (Fig. 2). Furthermore, yellow discoloration of the nails has been described during hemodialysis [7], in patients diagnosed with non-Hodgkin lymphoma [8]. Yellow nails can be also observed in patients diagnosed with diabetes mellitus (Fig. 3a, b) [9], tobacco-associated use (Fig. 4), or after intense use of nail polish remover (Fig. 5). In recent years, skin adverse reactions induced by cetuximab have been lately reported; cetuximab is a monoclonal antibody against epidermal growth factor receptor (EGFR) used in the treatment of colorectal cancer [10]. Recently, yellowish distal discoloration was observed in our department in a 67-year-old female patient treated with cetuximab for colorectal cancer (Fig. 6).
Acknowledgements Not applicable. Funding None reported. Availability of data and materials The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. Authors’ contributions AC contributed to the management of the patients, the conception of the work and the analysis of data. AN drafted the work, contributed to the proofreading and revising the manuscript. CP contributed to the management of the patients and has been involved in revising the manuscript critically for important intellectual content. SS contributed to the conception of the work and gave final approval of the version to be published. All Authors read and approved the final manuscript. Ethics approval and consent to participate All the patients consented to the publishing of the photos containing nonidentifiable images. Consent for publication All the patients consented to the publishing of the photos containing nonidentifiable images. Competing interests The authors declare that they have no competing interests.
* Correspondence: [email protected] 5 Department of Internal Medicine, University of Medicine and Pharmacy of Tirgu Mures, 38 Gheorghe Marinescu Street, 540139 Tirgu Mures, Romania Full list
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