Unraveling neuroHIV in the Presence of Substance Use Disorders
- PDF / 415,570 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 19 Downloads / 180 Views
GUEST COMMENTARY
Unraveling neuroHIV in the Presence of Substance Use Disorders Yu Lin 1 & Johnny J. He 2 & Roger Sorensen 1 & Linda Chang 3,4,5 Received: 21 October 2020 / Accepted: 26 October 2020 / Published online: 20 November 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
* Linda Chang [email protected]
3
Department of Diagnostic Radiology and Nuclear Medicine, and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
1
Division of Neuroscience and Behavior, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA
4
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2
Department of Microbiology and Immunology, Chicago Medical School, and Center for Cancer Cell Biology, Immunology and Infection, Rosalind Franklin University, North Chicago, IL, USA
5
Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA
J Neuroimmune Pharmacol (2020) 15:578–583
579
Abstract This special issue contains 10 invited review papers that highlighted and extended the presentations at the NIDA-sponsored workshop “Unraveling NeuroAIDS in the Presence of Substance Use Disorders” at the 25th Society on NeuroImmune Pharmacology conference in 2019. The topics covered by these papers focused on the interactive, additive or synergistic effects of substance use disorders (SUD) with HIV infection on the immune system and on neuropathogenesis. These papers reviewed four categories of substances of abuse (opioids, tobacco, stimulants, and cannabis) and how comorbid HIV infection (including models with HIV proteins, HIV transgenic rodent models and SIV) might further impact the dysregulated dopaminergic and immune systems, and the subsequent neuropathogenesis and behavioral disorders known as HIV-associated neurological disorders (HAND). These reviews provided detailed background knowledge regarding how each of these addictive substances and HIV individually or collectively affected the immune system at the cellular, molecular and system levels, and the subsequent clinical and behavioral outcomes. The authors also identified gaps, confounds or constraints in the current disease models and approaches, and proposed future research directions. Keywords HIV . Substance use disorders . Immune activation . Immunopathogenesis . Neuropathogenesis . Viral-host interaction . HIV persistence
This special issue highlights and extends some of the work presented at the 2019 pre-conference satellite workshop at the 25th Society on NeuroImmune Pharmacology conference, which was held on April 10-15th, 2019 in Portland, Oregon, USA. The pre-conference workshop “Unraveling NeuroAIDS in the Presence of Substance Use Disorders” was organized by two of our Guest Editors, Dr. Yu “Woody” Lin and Dr. Roger Sorensen, and sponsored by the National Institute on Drug Abuse of the U.S. National Institutes of Health. The workshop and this special issue focused on our current knowledge
Data Loading...
