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Competition for publication in Diabetologia continues to grow, and less than 20% of papers are accepted. Of all the high-quality papers that appear in this month’s issue I want to draw your attention to five articles that I think are particularly interesting. The articles are summarised here. Our publisher, Springer, has kindly made the full text of each of these papers freely available. I hope you enjoy reading them! Sally M. Marshall, Editor
Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men John A. Hawley, Paolo Sassone-Corsi, Juleen R. Zierath In the current ‘obesogenic’ environment there is growing popular and scientific interest in how the timing and frequency of meals impacts metabolic health, with an appreciation that the duration of which food is consumed effects numerous physiological and metabolic processes. Such ‘chrono-nutrition’ is aimed at optimising metabolism by timing nutrient intake to the acrophases of daily metabolic rhythms via manipulation of the feeding–fasting cycle. In this issue, Hawley and colleagues (https://doi.org/10.1007/s00125-02005238-w) review recent research from both animal and human studies demonstrating that dietary protocols incorporating chronic energy restriction, intermittent fasting and timerestricted feeding improve multiple cardiometabolic markers associated with obesity and type 2 diabetes risk. The figure in this review is available as a downloadable slide. Next steps in the identification of gene targets for type 1 diabetes
unlike other diseases, a single genomic region (HLA) constitutes ~50% of that genetic component. Much of the remaining genetic risk has been identified, with the vast majority of variants residing in DNA regulatory regions. In this issue, Grant et al (https://doi.org/10.1007/s00125-020-05248-8) provide a perspective on the transition from an allelic association to the effect of genetic variation on tissue-specific expression, identification of target genes of the associated variants and use of genetic data to identify those individuals at risk of type 1 diabetes prior to clinical presence of symptoms. The authors suggest that functional genomic studies, increased ethnic diversity of individuals included in such studies, and improved characterisation of chromosomal landscapes will be necessary to reveal novel prevention and treatment strategies. The figure in this review is available as a downloadable slide. Association of early-onset diabetes, prediabetes and early glycaemic recovery with the risk of all-cause and cardiovascular mortality
Struan F. A. Grant, Andrew D. Wells, Stephen S. Rich
Sung Min Kim, Gyeongsil Lee, Seulggie Choi, Kyuwoong Kim, Su-Min Jeong, Joung Sik Son, Jae-Moon Yun, Sin Gon Kim, Seung-sik Hwang, Seong Yong Park, Yeon-Yong Kim, Sang Min Park
Type 1 diabetes is characterised by young age at onset, requirement for exogenous insulin for survival and a strong genetic predisposition in the absence of family history. Genetics account for approximately half of total risk, yet,
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