Qualitative and Quantitative Data Analysis
The aim of most preclinical imaging studies is to derive qualitative statements about the matter under investigation, such as novel probes, therapies, pathologies, biologic mechanisms, mouse models, devices, or analysis methods. Multiple steps are commonl
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Small Animal Imaging
Basics and Practical Guide Second Edition
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Small Animal Imaging
Fabian Kiessling • Bernd J. Pichler Peter Hauff Editors
Small Animal Imaging Basics and Practical Guide Second Edition
Editors Fabian Kiessling Universitätsklinikum Aachen Aachen Germany Bernd J. Pichler Universitätsklinikum Tübingen Tübingen Germany
Peter Hauff Bayer AG, Drug Discovery Pharmaceuticals Berlin Germany
ISBN 978-3-319-42200-8 ISBN 978-3-319-42202-2 (eBook) DOI 10.1007/978-3-319-42202-2 Library of Congress Control Number: 2016959560 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface to the Second Edition
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations, and the new edition also includes an extended introduction to emerging technologies such as photoacoustic imaging, hyperpolarized imaging, and novel intravital microscopy techniques. The second edition includes a variety of other novel features: The section on “Special Applications” has been expanded to include chapters on metabolic imaging, cell tracking, transplant labeling, and imaging of infectious diseases. Additional useful hints are provided on the installation of a small animal unit, study planning, animal handling, and the cost-effective performance of small animal imaging. Furthermore, since many small animal imaging studies fail
