Quantitative assessment of disease severity of primary sclerosing cholangitis with T1 mapping and extracellular volume i
- PDF / 1,412,357 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 22 Downloads / 154 Views
HEPATOBILIARY
Quantitative assessment of disease severity of primary sclerosing cholangitis with T1 mapping and extracellular volume imaging Sehnaz Evrimler1,2 · Jordan K. Swensson1 · Vijay S. Are3 · Temel Tirkes1 · Raj Vuppalanchi4 · Fatih Akisik1 Received: 14 August 2020 / Revised: 16 October 2020 / Accepted: 20 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Assess the relationship between liver T1 relaxation time and extracellular volume (ECV) fraction and the disease severity of primary sclerosing cholangitis (PSC). Methods This retrospective study included 93 patients with PSC and 66 healthy patients in the control group. T1 relaxation times were measured in the right and left lobe, as well as in the area of stricture. T 1PSC and E CVPSC were calculated by averaging T1 and ECV of both lobes and stricture site. T1 and ECV were compared between the two groups and according to PSC phenotypes and severity based on Mayo Risk Score (MRS). We also examined the relationship between T1 and ECV with non-invasive measures of fibrosis such as Fibrosis-4 index (FIB-4) and liver stiffness measurement (LSM) by transient elastography. Results Mean liver T1 (774 ± 111 ms, p
Data Loading...
