Quantitative characterization of myocardial infarction by cardiovascular magnetic resonance predicts future cardiovascul
- PDF / 549,794 Bytes
- 7 Pages / 610 x 792 pts Page_size
- 10 Downloads / 197 Views
BioMed Central
Open Access
Research
Quantitative characterization of myocardial infarction by cardiovascular magnetic resonance predicts future cardiovascular events in patients with ischemic cardiomyopathy Hajime Yokota1, Shahriar Heidary1, Chandra K Katikireddy1, Patricia Nguyen1, John M Pauly2, Michael V McConnell1 and Phillip C Yang*1 Address: 1Division of cardiovascular medicine, department of medicine, Stanford university, Stanford, CA, USA and 2Department of electrical engineering, Stanford university, Stanford, CA, USA Email: Hajime Yokota - [email protected]; Shahriar Heidary - [email protected]; Chandra K Katikireddy - [email protected]; Patricia Nguyen - [email protected]; John M Pauly - [email protected]; Michael V McConnell - [email protected]; Phillip C Yang* - [email protected] * Corresponding author
Published: 9 April 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10:17 17
doi:10.1186/1532-429X-10-
Received: 18 February 2008 Accepted: 9 April 2008
This article is available from: http://www.jcmr-online.com/content/10/1/17 © 2008 Yokota et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Cardiovascular magnetic resonance (CMR) can provide quantitative data of the myocardial tissue utilizing high spatial and temporal resolution along with exquisite tissue contrast. Previous studies have correlated myocardial scar tissue with the occurrence of ventricular arrhythmia. This study was conducted to evaluate whether characterization of myocardial infarction by CMR can predict cardiovascular events in patients with ischemic cardiomyopathy (ICM). Results: We consecutively studied 86 patients with ICM (LVEF < 50%, mean LVEF: 26 ± 12%) with CMR before revascularization or medication therapy ± implantable cardiac defibrillator, determined the amount of myocardial scar, and followed for development of cardiovascular events. Thirty-three patients (38%) had cardiovascular events (mean follow-up: 20 ± 16 months). Patients who developed cardiovascular events had larger scar volume and scar percentage of the myocardium than those who did not develop cardiovascular events (16.8 ± 12.4 cm3 vs. 11.7 ± 12.6 cm3, p = 0.023 and 10.2 ± 6.9% vs. 7.2 ± 6.7%, p = 0.037, respectively). There were no significant differences in LVEDV, LVESV and LVEF between the patients with and without cardiovascular events (231 ± 76 ml vs. 230 ± 88 ml; 180 ± 73 ml vs. 175 ± 90 ml; and 25 ± 10% vs. 27 ± 13%, respectively). Conclusion: Quantification of the scar volume and scar percentage by CMR is superior to LVEDV, LVESV, and LVEF in prognosticating the future likelihood of the development of cardiovascular events in patients with ICM.
Page 1 of 7 (page number not for citation purposes)
Journal of
Data Loading...
