Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing
Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timelin
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Hamed Alborzinia
Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing With a foreword by Prof. Dr. Stefan Wölfl
Hamed Alborzinia Heidelberg, Germany Dissertation Heidelberg University, 2011
ISBN 978-3-658-10160-2 ISBN 978-3-658-10161-9 (eBook) DOI 10.1007/978-3-658-10161-9 Library of Congress Control Number: 2015941017 Springer Spektrum © Springer Fachmedien Wiesbaden 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, speci¿cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on micro¿lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a speci¿c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Spektrum is a brand of Springer Fachmedien Wiesbaden Springer Fachmedien Wiesbaden is part of Springer Science+Business Media (www.springer.com)
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To my parents, in love and appreciation!
Foreword by the Supervisor Laboratory in-vitro models that mimic in-vivo conditions to follow the response of cells to changes in their micro-environment, including treatment with drugs and toxic compounds, is still a challenging and demanding aim for scientists. In particular for drug research it is very important to know all the effects that can be triggered in mammalian cells when exposed to a bioactive, potential drug or toxic compound. Such a system will be very useful in the field of medicinal chemistry as well as for pharmaceutical companies. Newly synthesized compounds designed for therapeutic applications may not only act on their designated targets, but rather interfere with various biochemical pathways, which could have negative and beneficial impact on their application. These effects have to be carefully monitored before drugs can be used in therapeutic applications in the clinic. For this, all drug candidates and other chemical compounds are analyzed in great detail to understand their biological activities and modes of action. Nevertheless, many commonly used laboratory model systems are very limited. A major problem of most laboratory assays as well as animal studies is that the results are analyzed after a given treatment time in a so-called end-point assay. This means that after treatment is initiated th
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