Recap of Distinct Molecular Signalling Mechanisms Modulated by Histone Deacetylases for Cancer Genesis and Progression
Various post-translational modifications occurring mainly on N-terminal tails of histone proteins modulate their function. Histone acetylation being one of these modifications, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs
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Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy
Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy
Shabir Ahmad Ganai
Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy
Shabir Ahmad Ganai Sopore (Wadura), Jammu and Kashmir, India
ISBN 978-981-15-8178-6 ISBN 978-981-15-8179-3 https://doi.org/10.1007/978-981-15-8179-3
(eBook)
# Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
I dedicate this book to my wife Fatima Akhter, to my son Mohammad Faiq Ganai, and to my daughter Hafizah Shabir. While the writing of this book was ongoing, I was not able to give them company.
Foreword
Apart from the recent novel developments in cancer therapy such as immune checkpoint inhibitors or targeted agents focusing on altered cancer signaling pathways, the important role of epigenetic changes for tumorigenesis and tumor development as well as the potential of targeting these epigenetic changes as an alternative antineoplastic approach is increasingly accepted. In this context, the term epigenetics does not only refer to concepts that can explain how very different cellular phenotypes can arise without changes in the sequence or amount of inherited DNA, paradigmatic for the development of an organism but also to mechanisms in the cell nucleus that establish stable states of gene expression. Though it is increasingly well understood how mechanisms interact with each other to produce complex phenomena such as cell differentiation, gene dose compensation, or genomic imprinting, the question of how epigenetic changes interact in the development of malignant diseases and how we can target the
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