Histone Deacetylases: the Biology and Clinical Implication
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic d
- PDF / 3,953,413 Bytes
- 268 Pages / 439.37 x 666.142 pts Page_size
- 51 Downloads / 205 Views
Volume 206
Editor-in-Chief F.B. Hofmann, München
Editorial Board J.A. Beavo, Seattle J.E. Barrett, Philadelphia D. Ganten, Berlin P. Geppetti, Florence M.C. Michel, Ingelheim C.P. Page, London W. Rosenthal, Berlin
For further volumes: http://www.springer.com/series/164
.
Tso-Pang Yao
l
Edward Seto
Editors
Histone Deacetylases: the Biology and Clinical Implication
Editors Tso-Pang Yao Duke University Department of Pharmacology and Cancer Biology Durham, NC 227710, USA [email protected]
Edward Seto H. Lee Moffitt Cancer Center & Research Institute Department of Molecular Oncology 12902 Magnolia Drive Tampa, Florida 33612 USA [email protected]
ISSN 0171-2004 e-ISSN 1865-0325 ISBN 978-3-642-21630-5 e-ISBN 978-3-642-21631-2 DOI 10.1007/978-3-642-21631-2 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011936380 # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The discovery of histone deacetylase (HDAC) enzymatic activity was first reported in the late 1960s and, despite early prediction of the potential biological importance, histone deacetylation research was dormant for a long time. It took another 30 years before the first bona fide histone deacetylase, HDAC1, was purified and cloned in 1996, spurring an explosion of the HDAC field. In 2006, a book entitled “Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions” provided an excellent survey of work accomplished in the first 10 years (Verdin 2006). Since 2006, over 7,000 papers have been published on HDACs, affirming an exponential growth of interest in this topic. The purpose of this current book on HDACs is to serve as an update on the progress in this field within a relatively short 5 years. Particular emphasis is placed on discussions of many of the previously unexpected biological functions of HDACs in health and diseases and the tremendous progress in understanding the potential usefulness of HDAC inhibitors in the treatment of diseases. The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the devel
Data Loading...
