Recent advances in myeloid-derived suppressor cell biology
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REVIEW
Recent advances in myeloid-derived suppressor cell biology ✉)1, Nizar Mohammad Abuharfeil1, Homa Darmani2, Ammar Daoud3
Mahmoud Mohammad Yaseen ( 1
Department of Biotechnology and Genetic Engineering; 2Department of Applied Biology, Faculty of Science and Arts; 3Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
© Higher Education Press 2020
Abstract In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their role in non-cancerous pathological conditions remains in its infancy resulting in much confusion. Our objectives in this review are to address some recent advances in MDSC research in order to minimize such confusion and to provide an insight into their function in the context of other diseases. The following topics will be specifically focused upon: (1) definition and characterization of MDSCs; (2) whether all MDSC populations consist of immature cells; (3) technical issues in MDSC isolation, estimation and characterization; (4) the origin of MDSCs and their anatomical distribution in health and disease; (5) mediators of MDSC expansion and accumulation; (6) factors that determine the expansion of one MDSC population over the other; (7) the Yin and Yang roles of MDSCs. Moreover, the functions of MDSCs will be addressed throughout the text. Keywords non-human primates (rhesus macaques); myeloid-derived pro-inflammatory cells (MDPCs); autoimmune disorders; alloimmune responses; pregnancy; mature MDSCs; multiple sclerosis; Yin-Yang law of MDSCs
Introduction The identification of myeloid-derived suppressor cells (MDSCs) was first achieved in tumor-bearing mice and shortly after in cancer patients. Since then MDSCs have emerged as important regulators of immunity, and this is reflected in the immense research interest during the past decade, with more than 4000 articles related to MDSCs being published. Indeed, in 2019 alone, more than 650 articles were published, indicating that MDSCs have become an attractive research area. Although, the role of these cells has been extensively studied in cancer, in recent years the involvement of MDSCs in different non-cancer inflammatory conditions has also been highlighted. The latter include but are not limited to infectious diseases, autoimmune disorders, sepsis, stress, trauma, wounds/ injuries, aging, and organ/tissue transplantation, as well as pregnancy and lactation [1–8]. Since most of our knowledge about MDSCs has stemmed from cancer studies, it
Received February 8, 2020; accepted April 17, 2020 Correspondence: Mahmoud Mohammad Yaseen, [email protected]. edu.jo or [email protected]
will not be surprising to see a particular emphasis on the results obtained from cancer studies throughout the text. MDSCs are a heterogenous population of innate immune cells of myeloid origin that are best known for their ability to e
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