Recent Advances in the Synthesis of Perimidines and their Applications
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Recent Advances in the Synthesis of Perimidines and their Applications Nusrat Sahiba1 · Shikha Agarwal1 Received: 18 April 2020 / Accepted: 25 July 2020 © Springer Nature Switzerland AG 2020
Abstract Perimidines are versatile scaffolds and a fascinating class of N-heterocycles that have evolved significantly in recent years due to their immense applications in life sciences, medical sciences, and industrial chemistry. Their ability of molecular interaction with different proteins, complex formation with metals, and distinct behavior in various ranges of light makes them more appealing and challenging for future scientists. Various novel technologies have been developed for the selective synthesis of perimidines and their conjugated derivatives. These methods extend to the preparation of different bioactive and industrially applicable molecules. This review aims to present the most recent advancements in perimidine synthesis under varied conditions like MW radiation, ultrasound, and grinding using different catalysts such as ionic liquids, acid, metal, and nanocatalyst and also under green environments like catalyst and solvent-free synthesis. The applications of perimidine derivatives in drug discovery, polymer chemistry, photo sensors, dye industries, and catalytic activity in organic synthesis are discussed in this survey. This article is expected to be a systematic, authoritative, and critical review on the chemistry of perimidines that compiles most of the state-of-art innovation in this area.
* Shikha Agarwal [email protected] Nusrat Sahiba [email protected] 1
Synthetic Organic Chemistry Laboratory, Department of Chemistry, MLSU, Udaipur 313001, India
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Keywords N-heterocycles · Perimidines · Synthesis · Catalysis · Biologic activity Abbreviations CRF Corticotropin-releasing factor MW Microwave NDA 1,8-Naphthalenediamine HPA Heteropolyacids MCM Mobil composition of matter HBOB Bis(oxalato) boric acid PTSA P-toluene sulfonic acid CMK Nanoporous carbon DCM Dichloromethane THF Tetrahydrofuran β-CD β-Cyclodextrin RT Room temperature DDQ 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone DMSO Di-methyl sulphoxide PEG Polyethylene glycol MWI Microwave irradiations KB Kilobase of DNA/RNA MDR Multi-drug resistance MCF-7 Breast cancer cell lines Caco-2 Colon cancer cell lines Hep-2 Laryngeal carcinoma cancer cell lines WI-38 Fibroblast cell lines IC50 Value Half-maximal inhibitory concentration SAR Structure–activity relationship
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UACC-62 A panel of cancer cell lines TK-10 Renal cancer cell lines Ache Acetylcholinesterase LPS Lipopolysaccharides IL Interleukin TNF Tumor necrosis factor COX-2 Cyclooxygenases T47D Breast cancer cell lines H-522 Lung cancer cell lines Hepg2 Liver cancer cell lines HCT-15 Colon cancer cell lines PA-1 Ovary cancer cell lines HL-60 Leukemia cancer cell lines EW Electro
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