Recent genome duplications facilitate the phenotypic diversity of Hb repertoire in the Cyprinidae
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cent genome duplications facilitate the phenotypic diversity of Hb repertoire in the Cyprinidae 1,2
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Yi Lei , Liandong Yang , Haifeng Jiang , Juan Chen , Ning Sun , Wenqi Lv 1,3* Shunping He 1
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The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; University of Chinese Academy of Sciences, Beijing 100049, China; 3 Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China 2
Received May 29, 2020; accepted August 28, 2020; published online October 10, 2020
Whole-genome duplications (WGDs) are an important contributor to phenotypic innovations in evolutionary history. The diversity of blood oxygen transport traits is the perfect reflection of physiological versatility for evolutionary success among vertebrates. In this study, the evolutionary changes of hemoglobin (Hb) repertoire driven by the recent genome duplications were detected in representative Cyprinidae fish, including eight diploid and four tetraploid species. Comparative genomic analysis revealed a substantial variation in both membership composition and intragenomic organization of Hb genes in these species. Phylogenetic reconstruction analyses were conducted to characterize the evolutionary history of these genes. Data were integrated with the expression profiles of the genes during ontogeny. Our results indicated that genome duplications facilitated the phenotypic diversity of the Hb gene family; each was associated with species-specific changes in gene content via gene loss and fusion after genome duplications. This led to repeated evolutionary transitions in the ontogenic regulation of Hb gene expression. Our results revealed that genome duplications helped to generate phenotypic changes in Cyprinidae Hb systems. genome duplication, gene duplication, hemoglobin gene family, genomic organization, gene family evolution Citation:
Lei, Y., Yang, L., Jiang, H., Chen, J., Sun, N., Lv, W., and He, S. (2020). Recent genome duplications facilitate the phenotypic diversity of Hb repertoire in the Cyprinidae. Sci China Life Sci 63, https://doi.org/10.1007/s11427-020-1809-0
INTRODUCTION Whole-genome duplication (WGD), or polyploidization, is the most extreme form of gene duplication, which is a primary evolutionary source of new genetic material that creates phenotypic complexity and a key mechanism that allows novel gene functions to evolve (Comai, 2005; Huminiecki and Conant, 2012; Van de Peer et al., 2009; Van de Peer et al., 2017). Two rounds of WGD, 1R and 2R, occurred before the divergence of lamprey from jawed vertebrates during the evolution of vertebrates. They play an important role in the
evolutionary innovation of several vertebrate-specific features, such as the development of the nervous system, origin of the endoskeleton, and evolution of various signaling transduction pathways (Brunet et al., 2016; Flajnik and Kasahara, 2010; Hirano et al., 2011; Holland et
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