Recent progresses in marine microbial-derived antiviral natural products
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Online ISSN 1976-3786 Print ISSN 0253-6269
REVIEW
Recent progresses in marine microbial‑derived antiviral natural products Yun‑Fei Teng1,2 · Li Xu1,2 · Mei‑Yan Wei1 · Chang‑Yun Wang1,2 · Yu‑Cheng Gu3 · Chang‑Lun Shao1,2
Received: 21 July 2020 / Accepted: 13 November 2020 / Published online: 21 November 2020 © The Pharmaceutical Society of Korea 2020
Abstract Viruses have always been a class of pathogenic microorganisms that threaten the health and safety of human life worldwide. However, for a long time, the treatment of viral infections has been slow to develop, and only a few antiviral drugs have been using clinically. Compared with these from terrestrial environments, marine-derived microorganisms can produce active substances with more novel structures and unique functions. From 2015 to 2019, 89 antiviral compounds of 8 structural classes have been isolated from marine microorganisms, of which 35 exhibit antiH1N1 activity. This review surveys systematically marine microbial-derived natural products with antiviral activity and illustrates the impact of these compounds on antiviral drug discovery research. Keywords Antiviral activity · Marine microorganism · Marine natural products · Structure–activity relationships
Yun-Fei Teng and Li Xu have contributed equally to this work. * Chang‑Lun Shao [email protected] 1
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People’s Republic of China
2
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, People’s Republic of China
3
Syngenta Jealott’s Hill International Research Centre, Bracknell , Berkshire RG42 6EY, UK
Introduction Since viral diseases (such as HIV, H1N1, HSV, etc.) have always been seriously threatening human life and health, antiviral compounds are continuously special attention. Some existing viral diseases including AIDS, hepatitis B, influenza and other diseases that can cause millions of deaths every year have not been able to be eradicated completely. New viral diseases such as coronavirus are beginning to sweep the world, and related medical treatments are under investigation (Barlow et al. 2020; Li et al. 2020). Considering the importance of marine compounds in antiviral activity, the potency of some marine natural products to target SARS CoV-2 main protease (Mpro) (PDB ID 6MO3) was investigated (Khan et al. 2020) and reported the molecular docking analysis of 2019-nCoV inhibition by antiviral compounds from marine natural resources (Vijayaraj et al. 2020). Recent scientific studies triumphantly reported new antiviral agents, which generally inhibit the virus replication cycle through affecting the important host cell factor(s) for virus replication and/or viral elements (Lou et al. 2014). Despite the rapid development in antiviral pharmaceuticals over the past few decades, the emergence of recombinant viruses, drug resistance, and cell toxicity make it an urgen
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