Chemokine Receptors in Cancer
Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of liga
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Chemokine Receptors in Cancer Edited by
Amy M. Fulton
Cancer Drug Discovery and Development Series Editor: Beverly A. Teicher
For other titles published in this series, go to http://www.springer.com/series/7625
Amy M. Fulton Editor
Chemokine Receptors in Cancer
Editor Amy M. Fulton Department of Pathology School of Medicine Marlene and Stewart Greenebaum Cancer Center University of Maryland Baltimore MD 21201 USA [email protected]
ISBN 978-1-60327-266-7 e-ISBN 978-1-60327-267-4 DOI 10.1007/978-1-60327-267-4 Library of Congress Control Number: 2009921125 # Humana Press, a part of Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com
Preface
The chemokine receptors are a diverse family of seven-transmembrane G-protein-coupled receptors binding a large family of ligands. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This volume will summarize the growing body of evidence that several chemokine receptors contribute to tumor behavior. There is abundant evidence that CXCR4, which is widely expressed in many malignancies, contributes to the ability of tumor cells to metastasize to sites of ligand expression. Evidence for regulation of CXCR4 by hypoxia is described. Like CXCR4, both CCR7 and CXCR3 function to promote tumor cell homing and metastasis of melanoma, breast and colon cancers. Several chemokine receptors also function to support the survival and proliferation of tumor cells either directly or through transactivation by tyrosine kinase-coupled growth factor receptors. While chemokine receptors expressed on tumor cells generally support tumor growth and dissemination, expression of these receptors on host cells has both pro-tumor and anti-tumor functions. Both angiostatic and angiogeneic functions of CXC chem
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