Red Cell Distribution Width as a Marker of Periprocedural Myocardial Infarction in Patients with Elective Percutaneous C
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ORIGINAL ARTICLE
Red Cell Distribution Width as a Marker of Periprocedural Myocardial Infarction in Patients with Elective Percutaneous Coronary Intervention Chunfeng Dai 1
&
Zhangwei Chen 1 & Juying Qian 1 & Junbo Ge 1
Received: 29 May 2020 / Accepted: 15 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract We aimed to investigate whether red cell distribution width (RDW) was associated with periprocedural myocardial infarction (PMI) in patients undergoing elective percutaneous coronary intervention (PCI). Among 1723 consecutive patients undergoing elective PCI, a total of 230 (13.3%) met the diagnostic criteria of PMI. The high RDW (≥ 12.6%) group tended to have PMI (15.4% vs. 11.2%, P = 0.010). RDW was an independent predictor of PMI whether as a categorical variable (adjusted odds ratio = 1.442, 95% confidence interval = 1.088 to 1.911, P = 0.011) or a continuous variable (adjusted odds ratio = 1.236, 95% confidence interval = 1.079 to 1.415, P = 0.002). High RDW was also significantly associated with increased risk of major adverse cardiovascular events (MACE) during follow-up. However, anemia was not independently associated with PMI or MACE in the current study. In conclusion, RDW showed strong and independent association with PMI in patients undergoing elective PCI. Keywords Red cell distribution width . Periprocedural myocardial infarction . Percutaneous coronary intervention
Abbreviations CI Confidence interval CRP C-reactive protein cTnT Cardiac troponin T HR Hazard ratio MACE Major adverse cardiovascular events MCH Mean corpuscular hemoglobin MCHC Mean corpuscular hemoglobin concentration Chunfeng Dai and Zhangwei Chen contributed equally to this work. Associate Editor Craig M. Stolen oversaw the review of this article Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12265-020-10073-w) contains supplementary material, which is available to authorized users. * Juying Qian [email protected] 1
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China
MCV OR PCI PMI RDW
Mean corpuscular volume Odds ratio Percutaneous coronary intervention Periprocedural myocardial infarction Red cell distribution width
Introduction Red cell distribution width (RDW) is a parameter routinely reported in complete blood count analysis, which reflects the heterogeneity of erythrocyte volume in blood circulation [1]. It is traditionally used for differential diagnosis of anemias [2], but emerging pieces of evidence show that it correlates with the diagnosis and prognosis of several cardiovascular diseases like heart failure [3–6], coronary artery disease [7, 8], atrial fibrillation [9], and congenital heart disease [10]. Percutaneous coronary intervention (PCI) has become one of the standard medical procedures for the management of coronary artery disease, but adverse outcomes like periprocedural myocardial infarction (PMI) and maj
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