Renal Denervation A New Approach to Treatment of Resistant Hypertens
This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and
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Renal Denervation A New Approach to Treatment of Resistant Hypertension
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Renal Denervation
Richard R. Heuser • Markus Schlaich Horst Sievert Editors
Renal Denervation A New Approach to Treatment of Resistant Hypertension
Editors Richard R. Heuser St. Luke's Medical Center Phoenix, AZ USA
Horst Sievert CardioVascular Center Frankfurt Sankt Katharinen Frankfurt Germany
Markus Schlaich Baker IDI Heart and Diabetes Institute Melbourne, VIC Australia
ISBN 978-1-4471-5222-4 ISBN 978-1-4471-5223-1 DOI 10.1007/978-1-4471-5223-1 Springer London Heidelberg New York Dordrecht
(eBook)
Library of Congress Control Number: 2014954984 © Springer-Verlag London 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
In the Western world, 30–40 % of the adult population suffers from hypertension. The prevalence is expected to increase with the aging population. Sixty-five percent of patients over 60 years of age are affected by hypertension. It is thought to be the greatest risk factor for cardiovascular disease. Renal sympathetic efferent and afferent nerves are recognized as critical in the hypertensive disease process and represent an important therapeutic target. From the 1930s to 1950s, investigators performed surgical interruption of the sympathetic pathw
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