Gene and Cell Therapy: Biology and Applications
Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles,
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Gene and Cell Therapy: Biology and Applications
Gene and Cell Therapy: Biology and Applications
Giridhara R. Jayandharan Editor
Gene and Cell Therapy: Biology and Applications
Editor Giridhara R. Jayandharan Department of BSBE IIT-Kanpur Kanpur, Uttar Pradesh, India
ISBN 978-981-13-0480-4 ISBN 978-981-13-0481-1 (eBook) https://doi.org/10.1007/978-981-13-0481-1 Library of Congress Control Number: 2018950550 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Recent advances in stem cell biology, nanotechnology, and gene therapy have created new avenues for therapeutics. The availability of molecular therapeutics that rely on delivery of DNA, RNA, or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic, or induced pluripotent stem cells) have made a tremendous impact on translational medicine. The attached book chapters cover the various strategies for molecular and cellular therapies for human disease, including their advantages and challenges to their widespread applications. Potential solutions to these issues have been discussed elaborately. This book will provide an overview of advances on novel therapeutics and provide specific examples of disease conditions where these strategies have been translated to the clinic. The chapters also highlight state of the art into current research aspects of molecular and cell therapies. A summary of the chapters covered in this book is given below.
Part I: Gene Therapy Chapter 1. Retroviral Vectors in Gene Therapy Chitra Gopinath · Trupti Job Nathar · Everette Jacob Remington Nelson Gene Therapy L
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