Renin Angiotensin System and Cardiovascular Disease
The renin angiotensin system plays an essential role on cardiac and vascular functions and their connection in the generation of cardiovascular diseases. Renin Angiotensin System and Cardiovascular Disease covers indispensable aspects such as intracellula
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MD
Walmor C. DeMello · Edward D. Frohlich Editors
Renin Angiotensin System and Cardiovascular Disease
Editors Walmor C. DeMello Department of Pharmacology University of Puerto Rico P.O. Box 5067 San Juan PR 00936 Medical Sciences Campus USA [email protected]
Edward D. Frohlich Ochsner Clinic Foundation 1514 Jefferson Highway New Orleans LA 70121 USA [email protected]
ISBN 978-1-60761-185-1 e-ISBN 978-1-60761-186-8 DOI 10.1007/978-1-60761-186-8 Library of Congress Control Number: 2009933642 © Humana Press, a part of Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com
Preface
Experimental and clinical evidence supports the view that the activation of the renin angiotensin aldosterone system is involved in cardiovascular pathology including hypertension, heart failure, myocardial ischemia, and atherosclerosis. The present volume describes the intricacies involved in these processes, including the influence of prorenin/renin, angiotensin II, angiotensin (1-7), and aldosterone on cardiac and vascular functions as well as their involvement in the generation of cardiovascular diseases. Fundamental aspects like intracellular signaling, regulation of cell volume in the failing heart, and the presence of an intracrine renin angiotensin system are discussed. Moreover, the role of the mineralocorticoid receptor as an important component of the intracrine renin angiotensin system and as a regulator of extracellular action of angiotensin II is described, reinforcing the view that aldosterone inhibitors are helpful in the treatment of heart failure and hypertension. Let us hope the important topics included here motivate basic and clinical investigators and contribute to the development of new therapeutic approaches for cardiovascular diseases. We want to thank the distinguished authors and Humana Press for the opportunity to p
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