Three polymorphisms of renin-angiotensin system and preeclampsia risk
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GENETICS
Three polymorphisms of renin-angiotensin system and preeclampsia risk Chen Wang 1 & Xiao Zhou 1 & Huai Liu 1 & Shuhui Huang 1 Received: 18 June 2020 / Accepted: 6 October 2020 / Published online: 23 November 2020 # The Author(s) 2020
Abstract Purpose Some data suggest an association between the single nucleotide polymorphisms AGT T704C, ACE I/D, and AT1R A1166C and preeclampsia, but overall, the data are conflicting; the aim of our study was to discover a more stable and reliable association between these polymorphisms and PE risk. Methods A comprehensive literature search for this meta-analysis was conducted. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated to evaluate the strength, and heterogeneity test was conducted. Trial sequential analysis was also performed. Results A total of forty studies were finally included in our meta-analysis. The AGT T704C polymorphism was associated with PE risk in three genetic models (dominant OR = 1.33, 95%CI = 1.12–1.59; heterozygote OR = 1.26, 95%CI = 1.05–1.52; homozygote OR = 1.44, 95%CI = 1.14–1.83). No heterogeneity was observed in the three genetic models for the ACE I/D polymorphism. For subgroup analysis by geography, no significant association was detected. Significant associations were observed in mixed race, early-onset, late-onset, and more than 200 subgroups for the AT1R A1166C polymorphism; however, only one study was analyzed in these subgroups. Conclusions Our results indicated the AGT T704C and ACE I/D polymorphisms were associated with an increased risk of PE. Increased risks were also observed for the two polymorphisms in subgroups including Asians, Europeans, Caucasoid, and Mongoloid. Moreover, an increased PE risk with the ACE I/D polymorphism in the severe PE population was also detected. Regarding the AT1R A1166C polymorphism, weak associations were observed, but further studies are required. Keywords Polymorphism . AGT T704C . ACE I/D . AT1R A1166C . preeclampsia . risk
Introduction Preeclampsia (PE) is a common complication of pregnancy characterized by hypertension and proteinuria after 20 weeks of gestation [1]; it is one of major causes of maternal-fetal and Chen Wang and Xiao Zhou contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10815-020-01971-8) contains supplementary material, which is available to authorized users. * Shuhui Huang [email protected] 1
Department of Gynecology, Maternal and Child Health Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi, People’s Republic of China
neonatal morbidity and mortality worldwide [2]. Knowing the risk factors for preeclampsia is critical for its prevention and treatment. Genetic factors play an important role in the genesis and development of PE and the genetic susceptibility to preeclampsia has generated great attention; the T allele of AGT may play a role in the pathogenesis of PE reported by Aung et al. [3],which indicated the gene polymorphisms in the renin-angiotensin-aldoste
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