Reoviruses: Entry, Assembly and Morphogenesis
Reoviridae family members are large, complex viruses that infect human, animals, plants and insects. They are unique in that they lack lipid envelopes and package their genomes of discrete double-stranded segments of RNA within multi-layered capsids. Lack
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · P.K. Vogt, La Jolla/California H. Wagner, Munich
Polly Roy (Ed.)
Reoviruses: Entry, Assembly and Morphogenesis
With 42 Figures and 4 Tables
123
Polly Roy, M.Sc., Ph.D. Department of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine Keppel Street London WC1E 7HT UK e-mail: [email protected] Cover Illustration: Composite of Fig. 1C of chapter 6 (Patton and collegues) and Fig. 2A of chapter 1 (Dermody and collegues).
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Preface
Reoviridae family members are large, complex viruses that infect humans, animals, plants and insects. They are unique in that they lack lipid envelopes and package their genomes of discrete double-stranded segments of RNA within multi-layered capsids. Lack of a lipid envelope has allowed threedimensional structures of these large complex viruses (diameter, ∼ 600–1,000) to be obtained. Indeed the atomic structure of one of these viruses was the first large, highly complex structure ever solved, and subsequently has served as a model for other similar structures. The capsids of these viruses undergo cell entry and uncoating, the enzymatic functions necessary for transcription of the genome, and ar
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