Repeatability of small lung nodule measurement in low-dose lung screening: a phantom study
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RESEARCH ARTICLE
Open Access
Repeatability of small lung nodule measurement in low-dose lung screening: a phantom study Yu Du, Gao-Feng Shi* , Ya-Ning Wang, Qi Wang and Hui Feng
Abstract Background: Lung cancer screening revealed that people with small pulmonary nodules are mostly asymptomatic and that some of these people are at risk of developing lung cancer, so we intended to explore the repeatability of small lung nodule measurement in low-dose lung screening. Methods: We scanned eight ground-glass nodules (GGNs) and solid nodules, with diameters of 3, 5, 8, and 10 mm. They were divided according to the different combination schemes of tube voltage (KV) and tube current (mA) as 70, 80, 100, and 120 KV, and currents of nine tubes were divided as 20, 30, 40, 50, 60, 70, 80, 90, and 100 mAs. Results: Compared with the conventional dose group (120 kVp, 100 mAs), the nodule diameter and solid nodule volume measured by all scanning combinations were more consistent (P > 0.05), the volumes of 10 mm GGNs combinations were consistent (P > 0.05), the volumes of 8 mm GGNs were consistent (P > 0.05), the volumes of 5 mm GGNs combinations were consistent (P > 0.05), and the volumes of 3 mm were consistent (P > 0.05). Conclusion: In lung cancer screening, CT parameters should be as follows: tube voltage is more than 80 kVp, and tube current is 80 mAs in order to meet the requirements for the accurate measurement of the diameter and volume of pulmonary nodules. Keywords: Computer tomography, Low dose, Pulmonary nodules, Body model, Lung cancer
Background With the increasing popularity of lung cancer screening, the detection rate of small pulmonary nodules has increased. Lung cancer screening revealed that people with small pulmonary nodules are mostly asymptomatic and that some of these people are at risk of developing lung cancer [1]. Since the detection rate of small pulmonary nodules has increased, the subsequent problem is to determine how to deal with this as early as possible, and additional examination and treatment measures should be avoided. For malignant nodules, early diagnosis can provide a safer and clearer treatment plan. Considering * Correspondence: [email protected] Department of Radiology, the Fourth Hospital of Hebei Medical University, No. 12 Jiankang Rd. Changan District, Shijiazhuang 050011, China
the possibility of false positives, the computed tomography (CT) follow-up and monitoring of small nodules is very important. In addition, the possible radiation risk and economic cost of follow-up should also be comprehensively considered [2]. According to the International Lung Nodule Screening Guidelines, the size and growth rate of nodules are still well-recognized as important indicators to distinguish benign and malignant nodules [3, 4]. Compared with the nodule size in the first examination, the growth rate of the nodule can be calculated, in order to determine its benign and malignant nature. At present, the measurement of nodule size mainly includes diameter measurement, and the latest guidel
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