Resveratrol reverses the negative effect of alcohol on hydroxyapatite-coated implant osseointegration in senile female r
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Gerontologie+Geriatrie Original Contributions Z Gerontol Geriat https://doi.org/10.1007/s00391-019-01595-3 Received: 3 March 2019 Accepted: 23 July 2019 © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2019
Zhou-Shan Tao1 · Wan-Shu Zhou2 · Min Yang1 · Hongguang Xu3 1
Department of Trauma orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu, China 2 Department of Geriatrics, The Second Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu, China 3
Spine Research Center of Wannan Medical College; Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution; Dept of Spine Surgery, Yijishan hospital of Wannan Medical College, Wuhu, China
Resveratrol reverses the negative effect of alcohol on hydroxyapatite-coated implant osseointegration in senile female rats Introduction Total joint replacement is a common and successful orthopedic procedure that has successfully improved the quality of life but a variety of reasons for poor implant fixation lead to the necessity of revision total joint replacement [1]. The decrease in bone mass could cause a reduction in the supporting ability of an implant [2], especially osteoporosis, a chronic disease characterized by compromised bone strength mainly due to decreased bone mass and microarchitectural deterioration of the skeleton [3]. To solve this problem, some effective methods must be carried out and one approach to modifying the surface properties of implants is through application of a coating made of a biologically active material. Hydroxyapatite (HA)-coated implants are used for total hip arthroplasty, and clinical results show that the HA-coated prosthesis showed excellent bone formation, as in younger patients, indicating that biological fixation was possible also in older patients [4]; however, compared to implants in normal bones, the mechanical fixation of HA-coated implants in osteoporotic bones was unstable, even though HA coating improved bone formation around implants [5]. In addition to unmodifiable risk factors, such as age and sex, several nutri-
tional and lifestyle factors including low calcium intake and low physical activity are recognized as important risk factors for the development of osteoporosis [6]. Excessive alcohol intake is a wellknown to derange bone metabolism and cause of secondary osteoporosis [7]. A factor that plays a central role in alcohol-induced osteoporosis is the excessive generation of free radicals, which in turn causes oxidative stress and eventually leads to reactive oxygen species formation and increase in cytokine production [8]. Resveratrol (RES) is a natural nutrient from grapes. Recent studies suggest that RES is a potential candidate as anti-aging agent through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence [9]. Clinical and experimental studies have shownthat RES exhibited no toxic effects and can be safely used for prevention of bone loss by attenuating the damage
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