Retinoids Advances in Basic Research and Therapy
With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was pos
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Retinoids Advances in Basic Research and Therapy
Edited by C.E. Orfanos and O. Braun-Falco· E.M. Farber· Ch. Grupper M.K. Polano . R. Schuppli
With 215 Figures and 143 Tables
Springer-Verlag Berlin Heidelberg N ew York 1981
Prof. Dr. C.E. Orfanos Director Department of Dermatology University Medical Center Steglitz The Free University of Berlin Hindenburgdamm 30 1000 Berlin 45, West Germany
e-ISBN -13:978-3-642-68023-6 ISBN -13:978-3-642-68025-0 DOl: 10.1007/978-3-642-68023-6 Library of Congress Cataloging in Publication Data International Dermatology Symposium (1980 : Berlin, Germany) Retinoids, advances in basic research and therapy. ''Proceedings of the International Dermatology Symposium, Berlin, October 13-15, 1980." Bibliography: p. Includes index. 1. Psoriasis--Chemotherapy--Congresses. 2. Vitamin A--Testing--Congresses. 3. Acne--Chemotherapy--Congresses. 4. Vitamin A--Physiological effect-Congresses. I. Orfanos, Constantin E. II. Title. [DNLM: 1. Tretinoin--Therapeutic use. 2. Skin diseases--Drug therapy. QU 167 R438] RL32l.I56 1980 616.5' 26061 81-5769 ISBN-13:978-3-642-68025-0 (U.S.) AACR2 This work is subject to copyright All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, reuse of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to Verwertungsgesellschaft Wort, Munich. © by Springer-Verlag, Berlin Heidelberg 1981. Softcover reprint of the hardcover 1st edition
1981
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exemptfrom the relevant protective laws and regulations and therefore free for general use. Composition: Fotosatz Service Weihrauch, Wiirzburg 2127/3321 543210
Contents List of Contributors.
. .
. XIII
Introduction. C.E. Orfanos.
I
Pharmacology and Toxicology of Retinoids From Vitamin A to Retinoids: Chemical and Pharmacological Aspects. W. Bollag . Pharmacokinetics and Metabolism of Oral Aromatic Retinoids. U. Paravicini
5 13
In vivo Immunostimulating Properties of Two Retinoids: Ro 10-9359 and Ro 13-6298. Th. Hercend, M. Bruley-Rosset, I. Florentin and G. Mathe. . . . . . 21
Vitamin A Transport and Delivery and the Mechanism of Vitamin A Toxicity. DeWitt S. Goodman . . . . . . . . . . . . . . . . . . . . . 31 Experimental Toxicology of the Aromatic Retinoid Ro 10-9359 (Etretinate). K. Teelmann . . . . . . . . . . . . . . . . . . . . . . . . 41 Studies in Reproductive T9xicology and Mutagenicity with Ro 10-9359. H. Hummler and M.E. Schupbach. . . . . . . . . . . . . . . . . . . . . . 49 Cytogenetic Studies in Patients Treated with Oral Retinoid Ro 10-9359. R. Happle and A. Niedworok . . . . . . . . . . . . . . . . . . . . . . 61 Chromosomal Analysis in Patients Treated with the Oral Aromatic Retinoid Ro 10-9359. G. Obe and D. Tsambaos . .
